Advanced Organic Chemistry: Asymmetric Carbonyl Reduction

In this installment of the Synthesis Workshop Advanced Organic Chemistry course, Prof. Phillip Grant joins us to give a talk on the topic of asymmetric carbonyl reduction.

References (in order of appearance):
E. J. Corey, C. J. Helal, Angew. Chem. Int. Ed., 1998, 37, 1986-2012.
a) Hilborn, J. W. et al. Tetrahedron. Lett. 2001, 42, 8919–8921; b) Corey, E. J. et al. J. Am. Chem. Soc. 1987, 109, 7925-7926.
Noyori, R. Asymmetric Catalysis in Organic Synthesis; Wiley-VCH, 1994.
Noyori, R. et al. J. Am. Chem. Soc. 1989, 111, 9134–9135.
Qiao, L.; et. al. Chemical Communications. 2023, 59, 7518–7533.
Liang, J. et. al. OPRD. 2010, 14, 193-198.
a) Liang, J. et. al. OPRD. 2010, 14, 193-198; b) Zhao, H. et. al. Chem. Rev. 2021, 121, 12384-12444.

[craigsmith]

this was excellent. Carbonyl reduction is a hard topic to make interesting and you smashed it. Well done !!

[SIVAKUMARG-vksb]

An excellent talk and a wonderful topic...well done

[aidanlooby]

Fantastic video, one of my favorite concepts from my organic reactions and synthesis. Thanks to Xiafeng for putting this together and Thomas for problem set and of course Phillip for great content! Congrats to all!