E2 Reaction Mechanism - Hoffman Elimination vs Zaitsev's Rule

This organic chemistry video tutorial provides a basic introduction into the E2 reaction mechanism. The hoffman product is the least stable alkene and the zaitsev product is the most stable alkene. The hoffman product can be formed using a bulky base with a sterically hindered alkyl halide or using an alkyl fluoride.

Stereochemistry R/S Configuration:

Optical Activity & Specific Rotation:

SN1, SN2, E1, E2 Reaction Mechanisms:

SN2 Reaction Mechanisms:

SN2 - Test Question:

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SN1 Reaction Mechanisms:

Carbocation Stability - Hyperconjugation:

Carbanion Stability:

Protic Vs Aprotic Solvents:

E1 Ring Expansion:

E2 - Test Question:

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E2 Stereochemistry - Newman Projections:

SN1, SN2, E1, E2 - Practice Test:

Organic Chemistry PDF Worksheets:

Organic Chemistry 1 Exam 2 Playlist:

Full-Length Videos and Worksheets:

[ball]

zoned out of my three hour class and had no idea what was going on. Watched this 12 min video in class and now I'm ahead of everyone.

[GurleenKaur-xyxv]

not sure how my professors make it so complicated when you can clearly explain it to us in such clarity

[galyavakian]

I think you will save my life for my medical school entrance exam!! I really struggled in Organic Chemistry during finals!

[advayargade]

Thanks for clearly explaining the nooks and corners which are not that commonly taught. Really helpful!

[charlykhalil]

Best Organic Chemistry Tutor I love u man! I salute you!

[snazzyratking]

Oh my gosh I’ve been looking for the fluorine example everywhere! Thanks for explaining!

[frhneil]

hello sir, i'm wondering what it's take and how long it's take for you to understand this stuff let along teach it clearly in the most simple way ever? I'm amazed. I want to understand stuff till I can explain it just like you did.

[jewelokwuosa]

Thank's so much! quiz on this tomorrow, really helped : )

[atharvmathur]

Thank you soo much helped me a lot for my 12th grade exams😀

[akashprofile]

A lot of thanks, Brother!
You cleared my prolong confusion.

[nikodg]

The reason why the Hoffman product forms while e2 elimination of fluorine is due to enthalpy of the fluorine carbon and that's why it dont want to go easily at least that's what my profesor says

[rohankrishna]

Its excellent sir I learned a lot thank you so much sir

[xhegfim]

Thanks alot all my doubts is now cleared 😊

[lizareizis]

what makes a good or bad leaving group?

[yuridanylko]

Say there is a molecule (a triene) in which a bulky base is used to to create a hoffman product via an E2 reaction.

The first option will result in a cis disibstituted pi bond.

The second option will result in a geminal disubstituted pi bond.

There is also a trisubstituted pi bond possible towarss the middle of the alkene.

Will the major product be the cis or geminal alkene? What drives this? Stability of the carbocathion? Steric hindrance? Stability of the end product?

[alondraherrera]

didnt really explain what an e2 reaction is and how it works, do you have a video on that?

[qdmzqnt]

You are the BEST ! Thank you very much !

[albertlee]

If E2 is favored with a polar aprotic solvent is there a reason you use methanol for many of the solvent examples? Thanks for the video, super helpful for a quick MCAT review! Edit: type

[puneetgill]

for -O–CH(CH)3, will its preference be 1>2>3 because of steric hindrance?

[xxcoltonxx]

What about when its an alkyl group connected to a benzene ring, kinda need to know how to find the minor product there don't we....