Maternal malnutrition-induced epigenetic alteration linked to offspring hypertension

Maternal diet has profound, long-lasting effects on offspring. For example, maternal malnutrition results in fetal exposure to excessive glucocorticoid, which can result in metabolic reprogramming and hypertension. In this episode, Toshiro Fujita and colleagues exposed pregnant rodents to a low-protein diet or to the synthetic glucocorticoid dexamethasone and demonstrated that the offspring of these dams were prone to salt-sensitive hypertension. In utero glucocorticoid exposure resulted in aberrant DNA methylation of hypothalamic angiotensin receptor type 1a, resulting in increased expression. Moreover, mice lacking the DNA methyltransferase 3a became hypertensive in the absence of glucocorticoid exposure, while animals lacking the angiotensin receptor were protected from prenatal glucocorticoid exposure-induced hypertension. Together, these results reveal epigenetic modulation of angiotensin signaling underlies development of hypertension that results from prenatal exposure to glucocorticoids.