Sermorelin & Ibutamoren (MK-677) - HGH Secretagogues - Doc's Analysis of Side Effects & Properties

A physician’s analysis of Sermorelin & Ibutamoren (MK-677) and their side effects - two HGH secretagogues used more and more in “anti-aging” clinics and by people who just want to look fit. These two drugs achieve the goal of releasing HGH and increasing IGF-1, but do it through completely different mechanisms. One is legal by prescription (although there are legal risks for doctors prescribing it for cosmetic purposes) and one is not FDA approved, but manufactured “for research purposes only.” The idea with both is that they give some of the benefit of HGH, with less of the risk. But is it true? I take a look in this video, as well as discuss some of the side effects and results I’ve seen in patients who have used these drugs. Finally, I discuss my concerns with long-term use, including cancer risk with increased IGF-1.

TABLE OF CONTENTS:

01:40 - SERMORELIN
- Mechanism of action: synthetic analog of growth hormone-releasing hormone (GHRH)
02:17 - Clinical uses, in “anti-aging” (03:20)
03:52 - Legal risk for prescribing doctors
06:18 - Side effects: wide range of warnings
07:39 - What i see in my practice: limited effect
08:22 - Depression, anxiety, muscle pain, soft tissue injury, edema
08:58 - IBUTAMOREN (MK-677)
- Not FDA approved, a GH releasing peptide (GHRP)
09:48 - Mechanism of action: stimulates ghrelin
10:57 - Side Effects - counterproductive hunger
11:38 - Spillover on other hormones: edema, blood pressure, prolactin, lowered sex drive, more
12:29 - Anxiety, palpitations, heartburn, prediabetes, poor fasting glucose
13:06 - Used as "PCT" coming off HGH
13:38 - MY CONCERNS WITH HGH SECRETAGOGUES
- Is it sustainable vs. side effects?
14:15 - Cancer risk with IGF-1 increase
15:24 - Long-term cardio-metabolic effects

Stay Strong and Healthy,
Dr. O

____________

As the Anabolic Doc, since 2003, I’ve provided men who are using or have used anabolic steroids a confidential, ethical and professional medical venue to discuss their use. I do NOT in any way support the use of any performance enhancing drugs - PEDs, anabolic steroid or other medicine for muscle building or body transformation. The “off-label” use of PEDs, as such agents is considered illicit and may lead to adverse health outcomes. Please consult an expert health professional regarding any medical agent and do NOT use any medicine without the explicit advice and supervision of an appropriate medical expert.

This video is for education and information only. This is not medical advice. Only take medications as prescribed by your doctor. Do not take illegal substances. Taking steroids can lead to serious health consequences.

========================

[coolmaan]

Finally a review from someone who isnt promoting/sponsored by peptides/sarms. Thank you.

[joeo]

I love it! Personal opinions based on facts. No five alarm warnings, no its "good for everybody", no agenda to promote or dispel. You gave me the tools and information to make up my own mind. Thank You.

[zakariafadli]

I've been taking MK-677 for more than 8 months now and i'm healthy on it. My blood glucose is always below 80, no problems with sex drive, water retention seems to be only inside the muscle and not under the skin, pumps are great, can't really say anything bad about it. My dosage is 15mg every day and so far so good.

[kentwright]

Actually it is amazing to see the acceptance of this medication on a widespread basis by physicians. It is commonly available in online clinics that also treat patients for hypogonadism.

[SPM-tv]

A true doctor, when he says “amazing” he makes you smart and very stupid at the same time.

[bambinelas]

Such valuable information, thanks!!
What about a video over Cardarine?

[DeathToDrugUsers]

Been using mk677 for 11 months. One big benefit that is real is improved sleep

[michaelthomas]

Another great video. I love your approach to these topics. I thought about taking semorelin about 4 or 5 years ago, and the igf1 cancer concern was just too risky for me. So I just eat the best that I can, exercise, and drink lots of water. Thanks

[treygregory]

Really helpful and educational video. Thank you.

I had a friend ask for my opinion about taking SARMs and peptides. I had no idea how to answer. I found your channel and it has been a big help. These videos are probably more important than you realize.

[JCMW-hwjl]

Take Berberine with your Mk-677 to counteract blood sugar problems as a precautionary measure.

[mrpdmasta]

Huge fan doc. You looked at hairloss on sarms, but how about a video on Osterine. The most studied one of them all.

[itocc]

It's amazing to see how far we have gotten, with production of this enhancing drugs. It will only improve from this point, in my opinion. 200 years from now, I can only imagine the improvement.

[LOFIGSD]

2022, it would be really good if you could do a follow up, with more anecdotal evidence, great video.

[frankparish]

Another great video about something I've been very curious about... MK-677 made me so hungry I could not continue to take it. I used Sermorlin for 2 weeks and could tell it was making my GH spike. Thanks so much grest video.

[dhkeeferjr]

Awesome review, would love to see more reviews on peptides. Love your show.

[badralnimr]

You're doing a great job Doctor. It is truly educational.

[olegjohnkonings]

Been taking mk-677 12.5 mg a day for 7 months, /My IGF-1 was very low to start at about 101, and now is at 246. Have been getting blood tests every 2 months and no major changes in my markers other than IGF-1. Cortisol is normal, blood sugar rose slightly but still normal (80-90).
Gained about 5 lbs of (what appears to be) muscle from it, and my skin looks fantastic. Also seems to have healed some of my injuries, including some bone loss in my toe.
Worth the risk IMO.

[RT-pipv]

Cons on Sermorelin: I noticed depression, and reduced sex drive on Sermorelin. I also noticed an increase in HR and BP, although this could just be bc of the uptick in depression/anxiety. I noticed having a very hard time achieving orgasm.

Pros: exercise recovery was amazing (I’m an athlete). Notably, my cardio was insane, I never got fatigued. Increased strength/explosiveness. I also healed from injury much faster.

[jjakotya]

Absolutely awesome review Doc. I love all your reviews on all compounds and you Absolutely resonate with me and many others as you logical, unbiased with a wealth of proven knowledge from the ground up. Keep it up Doc your doing a fantastic job ❤👍😊

[tonyactorb]

Thank you for educating us and being honest.