CN 6: Abducens Nerve (Scheme, Pathway, Clinical Relevance) | Neuroanatomy

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Content:
0:00 Introduction
00:41 Abducens Nerve Scheme
01:53 Abducens Nerve Nucleus
04:05 Abducens Nerve Course
05:04 Lateral Rectus Muscle Function
06:25 Clinical Relevance
07:06 Recap

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Abducens nerve is purely a motor nerve supplying the lateral rectus muscle involved in abduction of the eye

Abducens/abducent nerve Nucleus:
- Nucleus of abducens nerve (nucleus nervi abducentis)
○ Facial nerve goes around this nucleus forming the facial colliculus (colliculus facialis)
○ A somatomotor nucleus that is located in the pons innervates the lateral rectus

Course:
- Emerges from the medullopontine sulcus between the pons and medulla oblongata
- Leaves the brainstem on the ventral side
- Runs on the base of the skull, penetrates the dura mater then enter the cavernous sinus
- Enters the orbit via the superior orbital fissure and common tendinous ring
- Then innervates the lateral rectus

Function of lateral rectus muscle:
- Abduction of the eye

Hering's Law of equal innervation:
- Coordinates both eyes together, so that the medial and the lateral rectus muscle contracts equally, while deactivating the contralateral muscle through the medial longitudinal fasciculus.

Clinical Relevance:
- Abducens nerve can get compressed by a lesion or rise in intracranial pressure.
- Compression causes paralysis of lateral rectus muscle, resulting in medial deviation of affected eye, giving a fully adducted eye at rest and an inability to abduct the eye.

Sources:
- Singh, I. (2017). Human neuroanatomy (10th ed.).
Helwany M, Bordoni B. Neuroanatomy, Cranial Nerve 1 (Olfactory) [Updated 2022 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-
- Kozlowski, T. (2017). Memorix Anatomy: The Complete Study Guide. 2nd ed. Thieme Medical Publishers.

Pictures and visuals:
- Complete Anatomy
- Biorender
- Powerpoint
- Camtasia 2021
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