PolyPhen-2 Tutorial Series: Interpreting a PolyPhen-2 Report

This tutorial describes how to interpret a results report from Polymorphism Phenotyping v2 (PolyPhen-2). PolyPhen-2 reports contain information about the query variant, variant effect prediction results, and additional details about the protein.

Key moments:
0:00 Introduction
0:16 PolyPhen-2 report overview
0:56 Locating query details
2:03 Locating and interpreting variant effect prediction scores
5:48 Accessing details about sequence alignment and 3D structure
8:00 Conclusion

Keywords:
PolyPhen-2, HumDiv, HumVar, UniProt, sequence alignment, variant effect prediction

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Hello dear administrator, can I collectively query the amino acid changes of a gene I have identified? It takes a long time to question them one by one. Thanks for your concern