Guo-Qiang Bi - Visualizing the multi-scale complexity of the brain - Monday Colloquium Oct 11, 2021

Visualizing the multi-scale complexity of the brain - by Guo-Qiang Bi, PhD

The brain is complex over multiple length-scales, from many protein molecules forming intricate nano-machines in a synapse to many neurons forming interconnected networks across the brain. Unraveling this multi-scale complexity is fundamental to our understanding of brain function and disease. In this lecture, I will introduce advances in visualizing the complex, multi-scale structures in the brain. Emphasis will be on new imaging techniques, including cryo electron tomography and correlative light-electron microscopy that enabled revealing in situ organization of synaptic molecules, and ultra-high speed volumetric imaging method VISoR developed to map brain-wide circuits at subcellular resolution. I will also discuss challenges and opportunities for interdisciplinary research collaboration to analyze and understand the enormous data generated by these cutting-edge technologies.

Monday Colloquium from October 11, 2021

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