Fatty Acid Activation | Beta Oxidation Part I

Before Beta Oxidation of Fats , the fatty acids are activated by the attachment of Coenzyme A in presence of an enzyme called Acyl COA Ligase.

Long-chain-fatty-acid—CoA ligase catalyzes the reaction between a fatty acid with ATP to give a fatty acyl adenylate, plus inorganic pyrophosphate, which then reacts with free coenzyme A to give a fatty acyl-CoA ester and AMP.
After the activation the fatty acids are transported to Matrix for oxidation.

[drecdec]

why we need to spend 2 ATP for this activation process...I mean the first ATP spent is for the reaction between Fatty Acid and CoA ---> activated Acil-CoA +PP (inorganic) +AMP ...but the 2nd ATP spent???? Where?? I red it is spent in order to receate ATP from the AMP produced but I don't see how

[mahira]

Sorry I didn’t understand why it had to be activated? Thanks for the video was really helpful!!!!

[mojojojo]

Hello sir can i get a playlist of this

[wallmethod]

Dude it’s “Acyl-CoA SYNTHASE” not LIGASE...

The fatty acid activation uses ATP yielding AMP + PP ultimately activating the Fatty acid “fatty acid Acyl Co-A”

[dudiqashmar]

Hey, How many high energy bonds are used for it?

[sumaira]

What is the significance of this fattyacid activation

[MorphfitTrainingSystems]

Show me Metabolism of BHB in Ketosis plz :)

[nifatjan]

Sir apologize 4 inconvenience ...actually m also frm d same valley n preparing for CSIR n need some help I.e y....