case 419 incontinentia pigmenti misdiagnosed as neonatal herpes simplex virus infection,

[dr.tageldinaly]

1.IP is an X-linked disorder involving mainly female neonate.
2. The first manifestations appear in the early days of life as progressive to four stages: vesicular, verrucous, and hyperpigmented, and hypopigmented lesions.

3. Other clinical features such as abnormalities of the teeth, eyes, hair, CNS, bone structures, and immune system can be observed in some patients

[dr.tageldinaly]

1.In this case, the prenatal history of genital herpes simplex infection of mother was a concerned problem in neonate, because HSV infection in neonates is potentially fatal or accompanied by CNS complications and early treatment with systemic acyclovir and continuing the oral treatment up to 6 months of life can make a better prognosis with lower rate of complications.

2. On the other hand, continuity of the skin lesions in our patient despite the proper treatment with acyclovir and a negative results of blood and CSF PCR suggested that a skin disorder is the main problem instead of HSV infection, and a consultation with a dermatologist and skin biopsy confirmed the diagnosis.

4. IP is an X-linked disorder
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