How We Go from Animal Model to Clinical Trial

Testing new treatments in other animals can help us spot complications or potential pitfalls, but the results don’t always carry over to humans, which means that safely going from animal to human trials is a lot more complicated than you might think.

Hosted by: Olivia Gordon
Camera Operator: Hiroka Matsushima

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[trevororchard]

Always respect the science boys and girls (rats and mice) for their continued huge contribution to humans.

[veronika]

Thank you so much for an awesome video on lab animals and their importance!!! I work for a company that makes heart valves and I was an animal husbandry technician, now I’m a surgical technician in the same department (working with lab animals). I love my job! And I love giving the animals a high quality of care while helping advance important heart valve research

[ctoroo]

I'm in 2nd year of B. Pharm. And this is very useful information.
Thank you SciShow😍

[SlyPearTree]

What if it does not work in animals but would have in humans?

[darkangel]

You should've mention how cruelly free products still use animal testing during the development process. They can use the label because the final product that is released to the public isn't tested on animals like prior formulations of that same product were

[MM-qppd]

End animal testing with Cytosolve technology by Dr. Shiva Ayadurai.He is the only hopeful who takes this extremely important and urgent issue on. And he is the only one knowledgeable and has the ability to invent this. It says a lot about a person or a nation by the way they treat the innocents especially children and animals. Thank you Dr. Shiva!!!

[thstroyur]

0:11 Rats may not be people, but Soylent Green is

[Master_Therion]

1:40 Those mice are called "knock out" because they are so attractive to researchers as animal models.
"Wow, look at that model, she's a knock out."

[veterinairesdupays]

Thank you for the update.

That's why vet medicine is of urge importance in research

[bigmike]

I'm curious if there were a drug that could save human lives but was deadly to every other animal would we ever be able to discover it?

[macbuff]

great informative and detailed presentation!

[purplealice]

I remember an old joke from Saturday Night Live's "Weekend Update"
...and this just in: "White mice cause cancer!"

[radzewicz]

Hi Olivia. Consider some of the gibberish that is being spread over butter vs margarine. What is butter? Butter is a suspension of milk solids in fat. what is margarine? Margarine is a suspension of milk solids in fat. So what's the difference? By law since 1943 (US) butter must contain animal fat, specifically dairy fat. margarine is a more general, generic term and butter is a form of margarine. so margarine can contain any type of fat, including walrus fat, should you so choose. To be realistic, heart-healthy margarines such as Promise or ICBINB are made with plant fats. Plant fats are liquid at room temperature so we call them oils. To make them more solid they are partially hydrogenated. However even after hydrogenation they still contain less than 1/3 the saturated fat of butter. And, like butter, they contain zero trans fat (read the friggin' labels!). So, bottom line, is that heart-healthy margarines are much better for your health than butter and neither is "one molecule away from being a plastic".

[nickvoelker]

You forgot the most import step: Secure funding. Most research dies at the animal testing phase simply because of a lack of funding to progress onto human trials. Step one really should be selecting an area of research where you can demonstrate that there's a potential for huge profits in the future. i.e. obesity research gets about $20 billion in funding annually. Not sure what they're researching though, not a whole lot of mystery in that area.

[angiebaby]

Scishow is the first channel i ever subbed to... I dont even know how long ago... So long lol

[ZacharyLaid]

Pigs are closely related to humans, hence the swine flu.

[ZanyGod]

With the number of clinical trials going on, this video illustrates the number of potential risks for the volunteers. Thank you. Excellent content.

[bigmike]

Also what is the ethical difference between experimenting on one animal versus another if neither is worthy of personhood?

[papinkelman]

Rats aren't people.
But a lot of people...

[JeremyWS]

Animal testing will always be needed. We mayn't like it, but animal testing will always be needed. I do think we need to treat the animals more humanely, but yes animal testing is still needed.