The stunning side effects of Ozempic | Johann Hari

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Broadcast on May 7, 2024

#davidpakmanshow #ozempic #johannhari

[emmadilemma]

We blame people for their obesity but our food system is set up to make people obese. Sounds like the way we blame people for being impoverished but we have a system that makes it so difficult to get out of poverty. I think our culture could benefit from some empathy all around. ❤❤

[whiteorchid]

I graduated HS in 1979 in a class of approximately 250 students. Maybe five or six students were visibly obese. But after Ronald Reagan became president in the 1980's he was the first president to deny Federal Agriculture Loans to thousands of Americas family farmers who then went bankrupt. The banks foreclosed and sold thousands of family farms off for pennies on the dollar to big corporate agro corporations who then monopolized Americas food production using genetically modified plants and toxic pesticides. Food processors extended shelf life by using chemically altered hydrogenated unsaturated fats the human body can't metabolize and put corn syrup and other sweeteners into everything even when it doesn't taste sweet because sugar is addictive.

[hikelfin]

As someone with severe lifelong binge eating disorder, Ozempic -- for the first time ever in my life -- has made me realise how food becomes unappealing after a standard portion. How it hits you like a brick in the stomach, and you can even leave food on the plate as you can't even stand the sight of food. It's made me happy in one sense but also so sad to know that this is how normal people just exist, and this has been broken in me my entire life. To me, I've never felt "full" or "satiated" from food. Like I'm drinking from a fountain but my thirst never goes away.

[bdharvey]

Please keep in mind that Wegovy is the version that is specifically for weight loss. Ozempic and Mounjoro is primarily for diabetics and insulin resistance. The weight loss is merely a side effect of the medication. celebrities have turned it into a fad diet, and caused immense shortages of the medication. They take it to lose <20 lbs. I take it to lower my A1C and help keep me alive. I am in a panic every month hoping that my prescription will get filled before my next injection is due. Thankfully insurance and pharmacies are starting to not cover Ozempic if they aren’t diabetic.

[dariusbates]

Really thoughtful conversation. Well done. Keep doing your thing Pakman - would love to see more from you on nuanced topics like this in the future.

[ginabee]

I started on 1mg of Ozempic/week awhile ago, but it didn’t help too much. Now that I have been on Ozempic 2mg/week, it's not just my PHYSICAL hunger that has lessened, but also my HEAD hunger decreased, as well. THIS is one reason that drugs like Ozempic helps people like me who eat past fullness. It has actually reduced my THOUGHTS about eating when I am not PHYSICALLY hungry.

[DollarDude]

I take Mounjaro for type 2 diabetes, and it has helped with my A1C levels immensely. I have also had the much welcome alternative effect of having lost over 200 pounds since my heaviest weight. Even though my fitness and lifestyle has changed significantly (I've since run several half marathons), I don't harbor any delusions of ever being able to stop taking this drug if I want to maintain progress.

[crunchydreams]

Intermittent fasting is the only thing that has worked for me. I eat healthy food and pay attention to my gut health also.

[wadp]

My wife is on Ozempic as she was overweight due to lipedema. Lipedema is a medical condition that primarily affects women. It causes fat buildup in the lower part of the body and the upper arms. No amount of healthy eating and exercise will eliminate this fat. Ozempic has been the only thing that has helped my wife lose weight.

Here’s a tip for the rest of us. Besides healthy eating, avoid as much as possible sugars and breads. Have your biggest meal in the morning and eat progressively less as the day goes on. Have very little, if anything, after about 3 or 4. This allows you to lose weight without starving yourself.

[FashionFunPJ]

America is one of the only countries in the world that has not banned the use of HFCS or limited the use of partially hydrogenated fats or who put major regulations on processed foods…because the companies which make them would lose billions of dollars and lobbyists would lose their jobs…and senators would lose their kick backs… same the pharmaceutical industry…it’s a very vicious circle

[arcticgoddess]

As someone with a long history of weight problems going back to childhood, I have white knuckled through low fat, low sugar, running, swimming, bulemia, it was a brutal job just to be normal to a bit chubby. I am an apple shape like the women in my family. It's the most vulnerable to obesity, diabetes and heart disease. I have rarely felt full. Until Ozempic. It was the weirdest thing. I could just 'take or leave' anything more than a bite or two of dessert. Due to age, depression and chronic pain, eating, and eating sugary crap, which I rarely allowed myself for decades has been something to look fwd to which is causing my health havoc. My Dr brought up Ozempic, as it's only $60 a month with my work insurance in Canada. (Americans, stop voting for Republicans who Vote against letting the US negotiate drug prices-you pay at least 5X as much as anywhere else and it's killing you.) Ozempic allowed me to lose 20 lbs in 6 weeks, which was awesome. The nausea sucked though. Now that I'm on disability, I hope to go back on, but I understand the depression and suicidality. When food becomes a friend and something to look forward to, it leaves a void. I need a better strategy filling that food with something I enjoy. Great guest. Don't care that he has a past - it probably makes him a better journalist now. We are too quick to cancel people, and no one is perfect, including you.

[Wackyjackieadventures]

This was a very interesting show. A breath of fresh air, from hearing about the orange man all day everyday everywhere! I’d love it if you did more shows like this. Thank you!

[fransinigiraldo]

One of my favorite episodes, David. I currently work extensively in obesity medicine and diabetes and like the author of the book, I see the benefits of these meds and feel the conflict of not addressing the real issue of food and feelings. Love it. Can’t wait to read his book. Thanks for this wonderful interview. Cuéntame si la tendremos en español también. Nuestros colegas de habla hispana necesitan esta información tan importante.

[Rita-ywtn]

My best friend almost died because of taking this medication for her diabetes but she lost so much weight and even if she ate anything she was going to the bathroom all the time and she dehydrated and she was very weak. She was already kind of petite but she was nothing but skin and bones. She stopped taking it and she looks so much better thank goodness she went back to her insulin and she’s doing fine now .

[justinwebb]

High fructose corn syrup preceded the rise of obesity by just a few years in America. Processed crap is killing us. We can choose to eat better. It takes effort. And im not talking about shopping at whole foods. Simply eating less and eating local and fresh is best.

[FatLittleBirdtheThird]

The way you described where suicidal ideation comes from when drastically changing our eating habits based on addiction is spot on and I hope people will start to discuss that more. For me there’s emotional eating as a method of self harm. Eating to cause pain. That should be part of the eating discussion as well.

[audreymuzingo]

Besides increased risk of self-harm, gastric bypass patients are at very high risk of developing one or more new addictions or leaning on ones they already had (other than food). And that's for the reason the guest described, where the sudden inability to buffer strong emotions by binging on favorite foods is suddenly not an option anymore. I am close to 3 people who had the surgery, and all 3 of them ended up with serious compulsions that were either brand new or under control before the surgery (drugs, gambling and sex).

[patricia_burkham]

I take Mounjaro. I have lost 50 lbs now in my 140s 5 foot 8 64 years old. Reversed my type 2 diabeties. Not going back!

[Craxin]

Manufactured foodstuffs tend to have a ton of appetite stimulating chemicals, are low satiating, and are calorically dense. It's no wonder we've gotten fat. We're so far from our sources of food, it means that corporations get to decide what we have access to, and it's going to be what makes them the most money.

[detrif]

Peter Attia also has observed that people who relied on Ozempic experienced substantial muscle loss. Muscle loss is highly associated with an increase in all cause mortality as one gets older.