Applications of high throughput gene expression profiling in early drug discovery

Presented By: Pieter Mestdagh, PhD

Speaker Biography: Pieter Mestdagh, PhD is a Senior Scientist at Biogazelle, as well as Associate Professor at the Faculty of Medicine and Health Sciences, Ghent University, Belgium. He holds Masters degrees in industrial Engineering and Biochemistry (2004), and Bioscience Engineering and Cell and Gene Biotechnology (2006), as well as PhD in Biomedical Sciences (2011). He is the author of more than 100 scientific articles in international journals, as well as the owner of six European Patents.

Webinar: Applications of high throughput gene expression profiling in early drug discovery

Webinar Abstract: Early stages of drug discovery often depend on relatively simple reporter assays or phenotypic readouts, providing little or no information on the drug’s mechanism of action (MOA). Gene expression profiling technologies like RNA-sequencing enable a more comprehensive characterization of compounds by measuring the activity of molecular pathways. This information can complement phenotypic readouts and can be used to prioritize candidate compounds for further testing. RNA expression profiling also serves as a generic test that can be applied to any drug development pipeline without the need for target-dependent customization.