Type 2 Hypersensitivity Reaction Made Easy Immunolgy

Type II hypersensitivity is an antibody-dependent process in which specific antibodies bind to antigens, resulting in tissue damage or destruction.

Type II hypersensitivity is mediated by IgM or IgG targeting membrane-associated antigens. A sensitization phase leads to production of antibodies that recognize substances or metabolites that accumulate in cellular membrane structures. In the effector phase, target cells become coated with antibodies, a process termed opsonization, which leads to cellular destruction by three mechanisms: (1) phagocytosis, (2) complement-dependent cytotoxicity (CDC), and (3) ADCC.

The most common cause of type II reactions are medications including penicillins, cephalosporins, hydrochlorothiazide, and methyldopa, which become associated with red blood cells or platelets leading to anemia and thrombocytopenia

[MamoonaSaleem]

I was just studying this topic, and your notification came up,
Thanks for posting it..
Please post the other 2 types soon..
I want to study them for my exams next week.

[namyachou]

Sir your lectures are amazing
I just love the way you make things so easy

[jyotirmoymukherjee]

Myasthenia gravis comes under ADCD(antibody dependent cellular dysfunction) not ADCC

[asmakanwal]

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[ageeshnaayyappan]

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[bhawanagahlot]

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[nidalaiya]

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[rukiee.b.ovwigho]

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[akshithar]

Type 2 is mediated by not only IgG but also IgM

[wizard]

Aren't antibody dependent cellular cytotoxicity (ADCC) and antibody mediated cellular dysfunction two different mechanism??

[martinsmarc]

ADCC involves NK cells that kill the cell

[OmarAli-pypq]

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[shaikhawes]

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[AmeerHamza-ivsn]

9:35 sir! Why antibodies develop against the normal cells in mysthenia Gravis?