[Webinar] Thermal Unfolding and Aggregation Analysis

When sorting through a heap of antibody candidates from a library, thermal stability and aggregation data help to separate the good from the bad and the ugly. Twist Biopharma, a division of Twist Bioscience, uses its proprietary DNA writing technology to create large diverse oligo pools (upwards of 106) to develop a range of antibody phage display libraries. These libraries are either broadly applicable to any target or focused on a specific class of tough targets, e.g. GPCRs. Screening Twist’s libraries often discovers a large panel of antibodies to each target, which can be further sorted based on biophysical performance.

In this webinar, Twist Biopharma will show how Uncle fits into their workflow to get an early read on stability, when sample volumes are small, to screen for the best candidates for development. Utilizing this data, they will show how they can winnow their lead candidates down to a smaller number of top candidates to pursue further.

Learning Objectives:

Learn about Uncle’s unique combination of biophysical screening techniques for conformational and colloidal stability
See the advantages of generating phage display libraries from large oligo pools
Understand Twist Biopharma’s capabilities to generate diverse libraries and identify new antibody candidates
See how Twist Biopharma’s workflows screen and refine libraries down to strongly binding, stable lead candidates
Speakers:

Aaron K. Sato, Ph.D.
CSO, Biopharma
Twist Biopharma, a division of Twist Bioscience