David Sinclair at ARDD2023: Epigenetic stabilization and reprogramming: an update

David Sinclair , Harvard Medical School, USA presents at the 10th Aging Research and Drug Discovery conference: Epigenetic stabilization and reprogramming: an update.

[MichaelMerritt]

They should work with Michael Levin’s lab who has shown there’s an electrical interface inside cells and the human body which controls the programming of cells and biological substrates. Like you can see the formation of biological formations like a face as electrical energy before a face is created for example.

[chrisyu]

I am particularly intrigued by your experiments involving the optic nerves of mice, where you have demonstrated the potential of these factors to repair and possibly rejuvenate damaged nerve cells. However, I have a couple of questions regarding the specifics of these experiments:

Distinction Between Nerve Regeneration and Repair: In your studies, how do you ascertain that the observed improvements in the optic nerves of mice are the result of the repair of originally damaged nerves, and not the regeneration of new nerve pathways? Since the reconstruction of neural pathways might lead to memory loss or other issues.

Direct Aging vs. Induced Damage: Your experiments involve inducing physical damage to the optic nerves before applying the Yamanaka factors. I am curious to know why this approach was chosen over directly inducing aging or degeneration in the nerve cells themselves. Would the latter not provide a more direct model of age-related neural degeneration?

Experiments on Naturally Aged Cells: Have there been any experiments where you applied Oct4, Sox2, and Klf4 to naturally aged cells, particularly in the context of nerve cells, to observe whether similar rejuvenation or repair effects are noted?

[-Brendon-]

Amazing and very in depth explanations. So excited for Dr. Sinclair's work on chemicals that will be cheap.

[Jessica-kkcz]

20 years is too long. These labs need funding, now, in the 100s of billions of dollars, and for “regulatory” agencies to get out of the way and stop interfering

[SilverFank]

Wow. Awesome event + attendance + David is rad

[peterm]

I would like to hear more from David Sinclair on recent progress on ageing

[andrewwalker]

Sinclair is a very gifted communicator. My only gripe is that one would be for given thinking that he invented partial cellular reprogramming. Needs to give a better nod to those coming before him IMO.

[markrobert]

There is no reason whatsoever to ignore the resvertrol scandal and move forward forming companies selling false hope

[tserenchimedaltangerel]

He is getting younger and younger, means that he already got that how to stop aging ❤❤❤

[Nahidofficial]

I've read his book lifespan couple weeks ago.. and thereafter I'm looking for his interviews

[DCGreenZone]

I have read that L Carnosine may reverse cellular senescence. That can't be a bad thing, can it?

[joeblow]

Goes on. "Hey everybody, its been 10 years" looks exacty the same as last time XD

[georgiaparaskevopoulou]

That is amazing!! I will like to hear more...l would like also read the book Lifespan!!😊by David!!

[kiwiingrid]

Haven't researched but my bet is BlackRock, Vanguard and Statestreet own all those companies.

[EdT.-xtyv]

13:00 🎯
21:00 epigenetic damage by certain institutions 🤔

[Thaythichgiachanh]

Thank you very much for your valuable information ♥👍👍

[joeschmoe]

FINALLY - FOR THE LOVE OF GOD - 3 MONTHS LATER.

[cuban]

Has anyone considered POMC and Leptin modulation in Ageing?

[christian-schubert]

"And the answer that we came up with was: PROBABLY" - weirdly enough the most scientific remark I've ever heard 😂

[Melanie____]

In the meantime you can effectively enhance your epigenetic expression and prevent dna damage with a whole food plant based vegan diet. (Ref pub med)