filmov
tv
KRAS mutation
Показать описание
This cancer pathway lecture explains about the KRAS mutation leading to the development of cancer.
Mutations of the k-Ras gene arise in over ninety% of pancreatic carcinomas. No different human tumor comes shut in mutational frequency. The ras pathway is most important within the transmission of growth-selling alerts from the telephone floor receptors, ultimately toward the nucleus where these alerts have an effect on the creation and regulation of other key proteins. It's exciting that despite the fact that most mutations in genes are expected to reason their inactivation, with the Ras genes the reverse happens - they emerge as more energetic in signalling. This is considering of the engineering design of the protein. The ras sign is became off by using a molecular switch, which depends upon an enzyme endeavor. In picturesque terms, the nucleotide GTP (guanidine triphosphate) engages the swap to maintain it within the "on" state. A component to the Ras protein has an enzyme endeavor (a GTPase) which cleaves the GTP. This turns the change "off" after the temporary "on" period. Definitely, the mutations of Ras do indeed inactivate a operate, as most mutations are anticipated to do. The GTPase is inactivated via the mutations. However this now signifies that GTP continues to interact the change, and the Ras signalling function is unable to be grew to become "off". A quantity of drug firms at the moment are investigating ways to abate the signalling perform of Ras, which might provide a rational cure for pancreatic cancer.
For more information, log on to-
Get Shomu's Biology DVD set here-
Download the study materials here-
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
We are social. Find us on different sites here-
Thank you for watching
Mutations of the k-Ras gene arise in over ninety% of pancreatic carcinomas. No different human tumor comes shut in mutational frequency. The ras pathway is most important within the transmission of growth-selling alerts from the telephone floor receptors, ultimately toward the nucleus where these alerts have an effect on the creation and regulation of other key proteins. It's exciting that despite the fact that most mutations in genes are expected to reason their inactivation, with the Ras genes the reverse happens - they emerge as more energetic in signalling. This is considering of the engineering design of the protein. The ras sign is became off by using a molecular switch, which depends upon an enzyme endeavor. In picturesque terms, the nucleotide GTP (guanidine triphosphate) engages the swap to maintain it within the "on" state. A component to the Ras protein has an enzyme endeavor (a GTPase) which cleaves the GTP. This turns the change "off" after the temporary "on" period. Definitely, the mutations of Ras do indeed inactivate a operate, as most mutations are anticipated to do. The GTPase is inactivated via the mutations. However this now signifies that GTP continues to interact the change, and the Ras signalling function is unable to be grew to become "off". A quantity of drug firms at the moment are investigating ways to abate the signalling perform of Ras, which might provide a rational cure for pancreatic cancer.
For more information, log on to-
Get Shomu's Biology DVD set here-
Download the study materials here-
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in YouTube. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
We are social. Find us on different sites here-
Thank you for watching
0:01:11
What is a KRAS mutation?
0:04:43
Understanding NSCLC Treatment When You Have a KRAS Mutation
0:13:59
KRAS mutation
0:01:08
What is a KRAS mutation in non-small cell lung cancer (NSCLC)?
0:01:42
Treating KRAS G12C Mutations
0:06:52
KRAS Mutations in Solid Tumors
0:01:34
Terri - How has your KRAS mutation affected the treatment options available to you?
0:07:57
Case 3: KRAS-Mutated Metastatic Colon Cancer
0:01:43
Survival Differences in KRAS/BRAF Mutations in mCRC
0:02:25
Cancer cell biology: mutated KRAS & reciprocal signalling
0:01:37
Treatment strategies for KRAS-mutant NSCLC with co-mutations
0:00:51
Personalized treatment approaches for patients with KRAS-mutant pancreatic cancer
0:03:46
Lung Cancer Treatments for KRAS Mutation
0:01:07
The case for separating G12D mutations in studying KRAS-mutant PDAC
0:21:36
Strategies for Overcoming KRAS Mutations
0:00:57
Dr. Cercek on the Need for Treatment Options in KRAS Mutated mCRC
0:02:26
Targeting KRAS mutations in lung cancer
0:02:31
How do doctors treat lung cancer with KRAS mutations?
0:00:41
Improving outcomes in KRAS-mutant pancreatic cancer
0:01:10
Targeting non-G12C KRAS mutations in NSCLC
0:01:05
RAS & Cancer: A Mighty Mutation
0:02:17
Sotorasib plus Panitumumab in KRAS-Mutated Colorectal Cancer | NEJM
0:01:48
Ask Ruby: What is KRAS?
0:01:35
The role of checkpoint inhibitors in KRAS-mutated NSCLC
Комментарии