RNA Editing in Brain Health and Disease

RNA editing catalyzed by adenosine deaminases acting on RNA (ADARs) occurs naturally at thousands of sites across the human transcriptome. This process profoundly affects gene expression and influences a wide range of human diseases from cancer to neurological disorders. In this webinar, Michael Breen discusses the role of ADAR-mediated RNA editing in neurodevelopmental disorders and how his team develops site-directed RNA editing therapeutics. He talks about studying RNA editing using transcriptome data and reporter assays and characterizing RNA editing across human brain regions, cell types, and brain development. Lastly, he introduces some concepts on using RNA editing as a therapeutic tool to correct diseases.