Antibody Structure: The Immunoglobulin Fold and Antibody-Antigen Interactions

Dr. KP gives an overview of antibody structure, and takes a look at a human antibody bound to the SARS-CoV-2 spike protein.

PDB IDs

REFERENCES
• Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.
• Chiu ML, Goulet DR, Teplyakov A, Gilliland GL. Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies (Basel). 2019;8(4):55. Published 2019 Dec 3. doi:10.3390/antib8040055
• Lambert, J. M., & Berkenblit, A. (2018). Antibody–drug conjugates for cancer treatment. Annual review of medicine, 69, 191-207.
• Nose M, Wigzell H. Biological significance of carbohydrate chains on monoclonal antibodies. Proc Natl Acad Sci U S A. 1983;80(21):6632-6636. doi:10.1073/pnas.80.21.6632
• Pan S, Manabe N, Yamaguchi Y. 3D Structures of IgA, IgM, and Components. Int J Mol Sci. 2021;22(23):12776. Published 2021 Nov 26. doi:10.3390/ijms222312776
• Vollmers, H. Peter, and Stephanie Brändlein. Natural antibodies and cancer. New biotechnology 25.5 (2009): 294-298.

[ianfefchak]

Hey Im an undergraduate biochemistry student and I have found your videos to be incredibly useful! I especially like your videos going over enzyme catalysis and as I am currently struggling to understand how FAD+ and FADH2 function as cofactors in enzymes I would forever be in your debt if you could make a video going over how they function! Thanks so much for the amazing content, keep up the good work!

[tstewpymol]

Great video! I'm one of the PyMOL developers and I would actually love to get in touch with you about how you went about making the images/animations for this video. My goal is to make it easier to view/visualize antibodies like these, while conveying meaningful information about their structure. Let me know if you have a business email or what is the best way to contact you!

[didierbarradas]

Excellent video, I really like the way you use the transition and the color selections, keep the amazing work 😉

[kundanboral]

Thank you so much for the video! Really helpful!