Automated CAR T cell manufacturing

The advantages of the CliniMACS Prodigy for the clinical-scale production of CAR T cells:

• automated CAR T cell production
• minimal hands-on-time from the operator
• sterile expansion in a single-use closed system
• supports both local and large scale production of CAR T cells
• standardized process for robust and consistent results

[guillaume]

How are the machine internals cleaned to prevent contamination from consecutive uses?

[Nat-ogjd]

is the transduction step also done by the machine?

[avanishmishra]

Very cool, it seems that positive magnetic selection was done to isolate cells from apheresis product. Cells are then expanded but how do you purify the labeled cells from expanded cells? Do you require de-beading?

[madhumathi]

So does the cells remain in the prodigy system for 10-14 days if performing end to end?