Precision Care and Health Disparities in Prostate Cancer

Presented By: Adam B. Murphy, MD, MBA, MSCI

Speaker Biography: Dr. Murphy has been studying the health disparities faced by minorities in prostate cancer, including Black and Hispanic men. His DOD and NCI R01-funded lab has been looking at the role of vitamin D deficiency, genetics, and biomarkers in men diagnosed with prostate cancer. Clinically he is interested in general urology and men's health and has appointments at Northwestern Medicine, Cook County Health and Jesse Brown VA Medical Center.

Webinar: Precision Care and Health Disparities in Prostate Cancer

Webinar Abstract: Data suggests that genetics comprises 42-58% of the prostate cancer risk. GWAS has found about 43% of the risk SNPs in Blacks and European Americans. Most of the SNPs that have been discovered are not associated with aggressive prostate cancer but are more common in men of African ancestry. The genetic variants account for the increased incidence of prostate cancer in Blacks and I posit that environment and namely social determinants of health account for the mortality disparity. We found that the rates of latent prostate cancer are 4-6 times lower in men of West African ancestry in Africa relative to both Black and White Americans. Further, I argue that the American environment itself accounts for the excess prostate cancer mortality seen in both White and Black Americans relative to Nigerian and other West African men.

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