Ankylosing Spondylitis | HLA-B27, Pathophysiology, Signs & Symptoms, Diagnosis, Treatment

Ankylosing Spondylitis: Causes, Risk Factors (ex. HLA-B27), Pathophysiology, Signs & Symptoms, Diagnosis, Treatment

In this lesson, we discuss an in-depth overview of ankylosing spondylitis, including what it is, risk factors, the association with HLA-B27 (and why HLA-B27 increases risk of ankylosing spondylitis), the role of gut microbiome in the pathogenesis, a variety of articular and extra-articular signs & symptoms of ankylosing spondylitis, X-ray findings (ex. Bamboo spine), how we diagnose it and how we treat it.

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JJ

****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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JJ

[heidinova]

I was diagnosed with HLA-B27 when I had anterior uveitis x2 and they tested me. My back hurt me enough today to need to leave work and I'm only 38. I'm an anesthesia provider at the largest hospital in my state, but no one seems to know about this. I would love permission from JJ Medicine to present this and talk about it at our grand rounds which is a morning teaching session we have every Thursday. We're a teaching hospital! :) Thank you for this very well done video <3

[gatewayz]

It’s a horrible disease, I was diagnosed at 29 and I’m now 54. I work full time and was in senior managerial roles but found stress made everything worse so I have a less demanding job. I still travel and have a great time and stay as active as my energy levels will allow. My spine is fused and I declined biologics due to the potential risks and complications. Getting in and out of a car is a challenge, putting socks on, picking things up off the floor and a very stiff neck are the main symptoms I have. The most worrying thing for me is the increased bouts of uveitis, it concerns me because I need my eyes to earn a living on computers so I pray it doesn’t result in a serious sight impairment. Good luck to anyone out there with it. Not many people bother researching it if they know someone with it so they don’t really understand. ❤

[colliecoform]

It is very important for doctors to diagnose women who present with symptoms. I was misdiagnosed for forty years because this was a "mans disease"! I was diagnosed at sixty after I had started to lean forward.

[maxallen-macdonald]

I too was finally diagnosed last fall with AS at 67 because it is "a man's disease". Apparently, more women like me are being diagnosed for a number of reasons including that rheumatologists are finally getting referrals from family physicians for women who have complained about back pain for years. And yes, I am HLA-B27 positive .

[tammyt]

My husband suffers from AS and is HLA-B27 positive. Thank you for sharing this video. It was very informative and eye-opening for me. He started experiencing pain around 16 years old and was diagnosed in his late 20's early 30's. Over the years he has been on many different medications and at 57 years old is currently on a biologic.

[joshuavansickel]

I'm now 37, and have been affected by this since I was around 19. The diagnosis started with a positive hla-b27 marker, later followed by mri results unfortunately my neck is completely fused with screws and rods due to an assault last year, but as a result I've had greatly diminished physical activity and have noticed my lower back has been significantly affected. Last week I was in the hospital (due to my neck hardware) and the mri taken has shown progressed inflammation, so that's going to be fun :). Anyway, video has pretty well hit every sign and symptom I've had over the years. Has been a joy to struggle with, for sure. If only I hadn't waited until my early 30s before really looking into it...

[getgive]

this was very helpful, I was diagnosed with this several years ago, though it was not explained to me this well, so thank you very much

[marystacey]

Thank you so much for all the detail. I started having neck pain when I was about 24-25. I was told by a doctor that I had some beginnings of arthritis in my neck.I'm getting ready to turn 55 next week. And i know now that I have ankyloingspondalitis as I just received my diagnosis. . It is definitely debilitating.I have to eat well and do yoga.I still have to work but there are definitely days where I wish that I had someone that could support me financially. I have terrible IBS and a few other problems you mentioned. I also have terrible headaches and recently found out that I tested positive for HLA-B27

[maxa]

Incredible lucid video. Thank you for helping people directly and indirectly for those who may not have this exact thing. A lot of people have to be their own advocate, this information helps the patient regain some power to act and the belief that it can get better. Amazing :)

[asserm.]

name one (1) youtuber with more extensive yet comprehensive and simplified videos, ill wait

[swine]

Im 31, co-diagnosed at about 20yrs old along with psoriatic arthritis (my psoriasis diagnosis was at 13yrs).

I will say... the three of them together are a force to be reckoned with....

[naysanarif]

have a pathophysio exam, and this video is an entire summary of my notes

[TheJeffrey]

This is an excellent discussion on AS. I have it taking Humira on a weekly basis. AS is debilitating for sure and I wish I would have been diagnosed 20+ years ago when it first started.

[MarkLawsonYK]

Thanks. Dx @ age 60. Back pain since mid 30's but always thought it was college and HS varsity sports.

[saddamhusain-yb]

Mujhe bhi 20 years se problem ho rha tha, now I feel good because of homeopathy treatment

[nainasharma]

I have been suffering from AS since 4 years roughly. Doctors just increased or decreased the nsaid dosage in all these years. After a time, the medicines also did not give any relief. Then, I switched to yoga. Trust me, it works as magic. I don't know of others but this worked for me. I do surya namaskar as many as I can, some general stretching, on chanting, pranayam, and few spine exercises seen from a physiotherapist on YouTube. I have so much relief. This is my experience with AS.

[trey]

My blood work came back today positive to this. I have zero issues with back pain, spine, joint, arthritis nothing. I do get iritis in my left eye occasionally and got it last month very bad I’m just now getting my eye sight back

[Inspoyouandfriends]

This was very helpful for my school work, Thank you very much for making this video!

[primatecarer]

It was helpful to learn that just because you are hla-b27 positive doesn’t mean you have or will get AS. And you can develop AS without testing positive. AND you can have AS AND fibromyalgia at the same time.

[brainnurture]

Thank you very much .You are explaining my case: :) I am suffering from AC and i am in my worst stage.Can't sleep at nights because of the severe pain.I have to move and move and move..:)