Manolis Kellis: Biology of Disease | Lex Fridman Podcast #133

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:

EPISODE LINKS:

PODCAST INFO:

OUTLINE:
0:00 - Introduction
2:49 - Molecular basis for human disease
26:48 - Deadliest diseases
32:31 - Genetic component of diseases
41:22 - Genetic understanding of disease
57:09 - Unified theory of human disease
1:03:10 - Genome circuitry
1:28:13 - CRISPR
1:39:50 - Mitochondria
1:47:54 - Future of biology research
2:17:30 - The genetic circuitry of disease

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[lexfridman]

Here are the timestamps. Please check out our sponsors to support this podcast.
0:00 - Introduction & sponsor mentions:
2:49 - Molecular basis for human disease
26:48 - Deadliest diseases
32:31 - Genetic component of diseases
41:22 - Genetic understanding of disease
57:09 - Unified theory of human disease
1:03:10 - Genome circuitry
1:28:13 - CRISPR
1:39:50 - Mitochondria
1:47:54 - Future of biology research
2:17:30 - The genetic circuitry of disease

[seabiscuit]

Manolis is the most concise explainer of abstract and complicated topics I've ever heard.

[eoxico]

Bring him every time you want. Manollis is simply amazingly inspiring

[tyfoodsforthought]

One of my favorite parts -
Manolis: "So, you have a bowl of noodles"
Lex: "Go on..."

Manolis is really such a great communicator. I deeply envy his students!

On another note, great to see you outside of your comfort zone, Lex!
That's where all the growth is.

[oulanakhle]

Lex please round 4 5 6 7... i can listen to this guy 4 ever

[christianbeske]

"Don't get me started" - Manolis Kellis catchphrase

[timf]

Me:*Sees 'Manolis Kellis: Round 3'
Also me: "Don't get me started!"

[DG-xgvg]

Started my PhD in Molecular Biology this month. I needed this. Thank you, Lex

[kylehendrix]

The first Monday of each month should be Manolis Monday on the Lex Friedman Podcast ❤

[alvechy]

What I love about Lex's podcasts is that such smart conversations are made for the audience. Manolis doesn't explain stuff to Lex, because many things he already knows, and they both know it. He explains to the audience. Lex doesn't ask some questions for him to understand, he may already know it, from own studies or from conversations outside the podcast. Lex wants the audience to know the answers. And for myself Lex is asking right questions at a right time. Just really great podcast.

[jasonfelice]

Don't forget... Lex is vital in our live for Manollis... Lex is half of this conversation.

So Lex, we want more of Manollis on Your podcast. Not just random talks from him.

You are complicit with our enjoyment here, so thank you too!

Not speaking for anyone else, but my guess is more commenting here feel the same.

You, like Joe Rogan, have a gift for bringing out the best in people.

[TheChaotyk]

A podcast that you can't listen to in the background is the best kind of podcast. It's so rich in information. Love it!

[Vertyskirty]

the way he breaks apart extremely complex concepts into simplistic steps is amazing.

[rogerzen]

Manolis' Youtube channel has the complete video of two of his computational biology courses . What a gift! He has a great way to explain super complex ideas in simple terms. Bravo!

[xushenxiong]

I feel so amazed, enlightened and enjoyable every time I listen to Manolis' wisdom! Thank you!

[maxlouisjansen]

I rarely comment on YouTube videos, but Manolis is such an inspiring guest. Keep the fun conversations coming.

[jamesmckeown]

Please keep bringing him on as many times as you are able, this guy is incredible

[moonoom]

gosh, I would love to hear a one hour in depth conversation about mitochondria!!

[rocknrolla]

Manolis is a fascinating personality. My favorite guest on your podcast

[jaroslavcech]

I can't get enough of Manolos! Could literally listen to him speak for hours on end! Lex I have to say I particularly like your guests talking about the universe and all its mysteries, especially when I'm out hiking sleeping in the woods, I find a meadow where I can catch reception and listen to your podcast while gazing at the stars! What a bliss, all thanks to your work!