Post covid Alzheimer's

69% higher risk of Alzheimer's for older COVID survivors

Older COVID-19 survivors,

69% higher risk of developing Alzheimer's disease,

within 1 year of infection

Medical records of 6,245,282

65 years and older

Medical visits but no previous diagnosis of Alzheimer's disease

February 2020 to May 2021

410,748 participants tested positive for COVID-19

5,834,534 did not test positive

COVID-19 survivors had a 69% higher risk of a new diagnosis of Alzheimer's disease within 1 year of infection than their uninfected peers

Hazard ratio 1.69; 95% (1.53 to 1.72)

Most at risk

Ages 85 and older, HR = 1.89

Women, HR = 1.82

Association of COVID-19 with New-Onset Alzheimer’s Disease

Journal of Alzheimer's Disease, vol. 89, no. 2, pp. 411-414, 2022

13th September 2022

Infectious etiology of Alzheimer’s disease, postulated for decades

So, is SARS-CoV-2 infection associated with increased risk for Alzheimer’s disease?

Retrospective cohort study

N = 6,245,282 older adults (age ≥65 years),

People with COVID-19 were at significantly increased risk for new diagnosis of Alzheimer’s disease

Within 360 days after the initial COVID-19 diagnosis

Propensity-score matching

COVID-19 cohort = 0.68%

non-COVID-19 cohort = 0.35%

(hazard ratio or HR:1.69)

TriNetX Analytics Platform

de-identified electronic health records

Over 95 million patients

Inpatient and outpatient visits

68 health care organizations

28% of the US population

50 states, covering diverse geographic, age, race/ethnic, income, and insurance groups

Our findings call for research to understand the underlying mechanisms and for continuous surveillance of long-term impacts of COVID-19 on Alzheimer’s disease

Not clear whether COVID-19 triggers or accelerates development of Alzheimer's disease

SARS-CoV-2 has been associated with inflammation and central nervous system disorders

Prior infections, especially viral infections, and inflammation

Dr. Pamela Davis

We thought we had turned some of the tide on it by reducing general risk factors such as hypertension, heart disease, obesity and a sedentary lifestyle

Now, so many people in the U.S. have had COVID and the long-term consequences of COVID are still emerging.

It is important to continue to monitor the impact of this disease on future disability

Plan to continue studying the potential effects of COVID-19 on Alzheimer's,

and other neurodegenerative diseases,

whether certain populations may be especially vulnerable

Assess, any drugs could be repurposed to treat COVID-19's long-term effects

[lindacharron]

My husband is 54 years old, he was 52 when he got covid in march 2020. He is still unable to work. I have to call him several times a day to remind him of things he needs to do. He forgets more than he remembers. I find it so hard coping with this, I have to work, he isn't getting any financial help, has put in for disability, but still not approved. It's exhausting to have to do the thinking for 2 people.

[LondonSteveLee]

All I know is from a (luckily) practically stroke-free family for generations there have now been eight strokes in three formally healthy people in my family in the last two years – all of them had recently received a certain recommended medical procedure. There is absolutely zero doubt in my mind as to the cause - a nurse in the family also said she'd never seen so many strokes.

[martinwebb]

Thanks John, as someone who cares for someone who has advanced Alzheimer's I wouldn't wish the condition on my worst enemy. Its soul destroying for both patient and carer. Thanks again John for all the continued reporting.

[charliesmith]

Thank you for posting this video. I have horrible brain fog from my battle with COVID. I went from feeling 40 to 90 after my Covid battle. I have about every post Covid symptom to this day and it is hard to want to continue living this way. People have no idea how terrible this is unless you have it. Please hang in there my friends if you are struggling…

[Marie.b]

My dad is in his mid 70s and during covid, he developed altzimers! Before lockdown he was cycling, driving, line dancing, socialising etc . I live 4 hours away and so it was through phone calls and the odd video chat that I saw the change. I thought he caught covid but would recover and get back on form but he didn't. In few months he deteriated to the point that he can't be trusted to take his medications or pay his bills and gave up driving because he bumped into the back of someone. He can't string a cohesive sentence together, remember names. It's really sad and now my suspicions are verified by this report.

[jostott]

My Mother had a slow progressing Alzheimer's. At the start of the lockdowns here in the UK she was grand with support from us her daughters, still going to the haridressers and was able to follow her routine with my Dad. 3 days after her first 💉atbthe end of 2020 she declined at such a rapid rate it, terrifed us and the decline continued until she had her first booster early 2021 and a week later she declined rapidly again. 1 month later she was placed in a care home and 12 weeks after that to the day, she was moved to a nursing home in end stage Alzheimers. My Dad did struggle to adjust to life without his girl by his side but we rallied as a family and got him through it but August last year we noticed some worrying behaviours nit put it down to stress and ambiguous grief. Unfortunately he wasn't coping very well and we found him wonderful sheltered housing apartment but in November 2021, 4 days he received his 3rd booster and the day after his cognition fell off the charts and continued at such a rapid rate with a few short months he was diagnosed with complexed mixed Dementia and unfortunately is now in a care home and is rapidly losing all of grip of reality. This is a man who in January 2020 was planning a family holiday for their 60th wedding Anniversary, he was a confident forthright man who was still driving and was considering buying another little sports car to tinker with and was planning home improvements for that year, so you will have to excuse my cynicism, as I will never accept that it wasn't the 💉 that did this to them as neither of them had had Covid and I strongly believe this is only the tip of the iceberg of what's to come to those who have been 💉

[annemeredith]

Thank you John. It is shocking that this is happening to so many. It must be so difficult for you to report every day so much sickness and disease throughout the world that just keeps accumulating. If this is all intentional, the lack of love and compassion for this suffering is mindboggling and unhuman.

[nickolas]

My aunt was 67 and healthy. Still working. Got her 3rd shot in march and now is in a nursing home starring at the ceiling. She didn't get covod but she did get the shot

[tishfoster]

My sister at 54 has early onset dementia. A year ago she had the first jab. Overnight she developed Parkinson’s type tremors interspersed with muscular spasms in her arms and legs. She lost the ability to feed herself. She had the second jab three months later … recommended by the local health department! Her physical and mental regression thereafter
was very rapid. More like free fall…. She is now in the final stages of the disease. Very very difficult to watch.

[kmbergeson]

The gift that keeps on giving. So sick of what our governments have done to us all.

[altonruss]

Alzheimer's and prion diseases were also a concern of mRNA vaccines in animal trials. Spike and even more concerning was the lipid nanoparticles (no matter the antigen) going back at least as far back as 2017. I'm sure the concerns are much older than that. So, COVID or vaccine, we could have a mess.

[msmama]

Thank you for keeping us informed. My father and grandmother had Alz. It is devastating.
Thank you again.
Blessings, take care.

[dave]

I'm 64 and long Covid has hammered me, I'm very aware of the effect on my thought processes and general sense of well-being. That's hard enough to deal with as I'm fully aware of things "not being quite right". There's not enough acknowledgement of the effects of Covid aside from the physical. Thanks for your videos Dr John.

[azannor]

Thank you Dr. Campbell for your continued covering/reporting of current medical events.

[thecorbern]

I agree that we need to know jabbed vs non jabbed in this study.

[susanbreeland]

Thank you so much for such intense studies thru all of this!! I was just talking to a close friend this morning who has suddenly started misplacing things of very much importance to her everyday life. I often forward your findings but think I will skip this one. She is aware something is going wrong. I stay in close contact with her and may tell her about your findings!!
I am the one that Maderna caused to have a stroke.

[Jack-louc]

My grandma had dementia when COVID hit, she declined and passed away quickly because of the isolation. Never forgive the lockdown measures! Also to mess with funerals was a disgrace

[roywall]

My 93 year old grandmother developed severe and sudden dementia during the mandatory lock downs. Locking her up and forcibly isolating her has ruined her quality of life. I will never forgive the bastards that did this to her.

[finglishman]

A great research video as always. It would be interesting to know other factors as well, such as jabbed and unjabbed. We knew someone who had mild Parkinsons disease. Their condition seemed to deteriate rapidly after the 1st of 3 vaccinations. A few months after the 3rd they sadly passed away. I must mention that the person concerned did not have covid during this period either. This person was very close to us 😔

[zofiasizer]

Very interesting. My mum developed dementia a few months after getting Pfizer covid vaccine (she contracted covid a year later). She was 81 no signs of forgetting before that. Strange thing is that I know other 2 ladies who developed dementia over last two years!