Better Cognition Seen with Klotho Gene Variant Carried by 1 in 5

A scientific team led by the Gladstone Institutes and UC San Francisco (UCSF) has discovered that a common form of a gene already associated with long life also improves learning and memory, a finding that could have implications for treating age-related diseases like Alzheimer's.

The researchers found that people who carry a single copy of the KL-VS variant of the KLOTHO gene perform better on a wide variety of cognitive tests. When the researchers modeled the effects in mice, they found it strengthened the connections between neurons that make learning possible -- what is known as synaptic plasticity -- by increasing the action of a cell receptor critical to forming memories.

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