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Pharmacology - DRUG INTERACTIONS (MADE EASY)
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Multiple drugs are often used in clinical practice because patients frequently present with multiple chronic diseases. Several medications are frequently administered concurrently to improve drug adherence. Although this may be a preferred clinical strategy, administering two or more drugs at the same time increases the possibility of drug-drug interactions. As the risk of drug-drug interactions rises, so does the risk of debilitating, even fatal, adverse drug events.
This pharmacology lecture discusses various mechanisms of CYP450-mediated drug-drug interactions including competitive, non-competitive and irreversible inhibition.
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0:00 Intro
1:40 Active Site and Allosteric Site
2:47 Binding Affinity
4:32 Intrinsic Clearance
6:05 Competitive Inhibition
9:09 Non-Competitive Inhibition
10:18 Mixed inhibition
11:02 Irreversible Inhibition
This pharmacology lecture discusses various mechanisms of CYP450-mediated drug-drug interactions including competitive, non-competitive and irreversible inhibition.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
1:40 Active Site and Allosteric Site
2:47 Binding Affinity
4:32 Intrinsic Clearance
6:05 Competitive Inhibition
9:09 Non-Competitive Inhibition
10:18 Mixed inhibition
11:02 Irreversible Inhibition
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