Is Modafinil (Provigil) Really A Smart Drug?

[davidbmason]

I don't have any scientific papers to back me up at this stage but I guarantee it improves my focus and attention. Surely a wakeful and focussed brain can work and study longer which would make it a smart drug, It has replaced amphetamines as a stimulant used by air force pilots. It surely isn't a limitless drug but besides amphetamines, it does a pretty good job at increasing focus and attention.

[takeiteaseokay]

I honestly hope you’re a professor because you have explained the effects of dopamine /neurotransmitters simpler and more effectively than my Pharmacology and Anatomy professors. What could’ve taken me 3-5 times of repeating, you explained once. Your explanations are direct!!! At least for me, so thank you!!!! Keep up the good work !!

[GrantValdes]

I appreciate that you're bringing an actually informed perspective to this topic on YouTube. That said, I have a wild new puppy, and as a result haven't slept through the night once for the past month. I've self-medicated with Modafinil, just a few days per week, and it does help. It's only a short-term scheme and I do assume I'm damaging myself. This is the sort of context in which I would recommend people consider it -- not in order to become Magic Bradley Cooper.

[stephenderong]

I equate Modafil to your best night's sleep. When you feel good you perform well. 1 caveat, I end up crashing about 24 hours later.

[rgones]

I see you state that "The ones that show improvement are studies preformed on those with cancer fatigue, MS, or other serious disease states" or sleep deprivation.

Citation needed? I agree, the nootropics community is a buch of snake oil sellers, but I don't think this shuold be any reason to dismiss proper clinical trials or cherrypick them. 
I have just scoured PubMed for a couple of minutes and I've found two meta analysis with interesting findings (175 and 31 primary literature studies respectively). Here are the extracts.
- Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review.- Battleday RM, Brem AK
"We found that whilst most studies employing basic testing paradigms show that modafinil intake enhances executive function, only half show improvements in attention and learning and memory, and a few even report impairments in divergent creative thinking. In contrast, when more complex assessments are used, modafinil appears to consistently engender enhancement of attention, executive functions, and learning."

- Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review.
- Repantis et al.
"Modafinil on the other hand, was found to improve attention for well-rested individuals, while maintaining wakefulness, memory and executive functions to a significantly higher degree in sleep deprived individuals than did a placebo."

[jontatum]

Thanks I almost got prescribed this med, I did some research on it before and found in reviews a lot of people liked it but not for the reason I need it for

[rozorahk]

Modafinil only increases my focus in the mornings and into the late afternoon when I get sleepy. If I take it at night when I’m already awake (night owl) I notice nothing. Aside from that, it doesn’t improve my executive function at all. Doesn’t improve my cognition either. I honestly make more mistakes. It’s basically the worlds best coffee without all the diuretic bs of caffeine.

[thejking]

So how do you explain my increased focus after taking it?

[farzanfarajizade]

yes, dopamine receptors must be discussed not the dopamine itself; but there many other receptors which are involved in Modafinil mechanism of action; and absolutely Modafinil is a cognitive enhancer drug mostly by means of acting on glutamate receptors which must not get ignored in a conclusion you made.
by the way thank you.

[Letmeberhereinurheart]

Also, if you are referring to a specific study (5:06.) Appreciation would be given for some links in the description if available online/ possible.

[vincentsherlock]

I prefer Fluormodafinil (stack it with Piperine + Semax + Noopept and NSI 189).

[ontoereikendheid]

You work in a hospital, are you working in relation to pharmacology? Would love to know what degree path you took to get into this position.

[miguelgimenez]

excellent video ! . I have a question, what about the oxiracetam or the other racetams family ?

is the smarts drugs actually exist ?

[korennahlavinka]

What should someone take if they have narcolepsy and adhd???

[snexo]

Very well explained. Thanks! Some smart drugs recommendations? Not the ones you mentioned in the video.

[Letmeberhereinurheart]

Sorry the question is kinda unrelated; Do you have a video on/ know much about Memantine? (Namenda) It has a history of its use in Alzheimer's/Parkinson's disease based off of my own research and is said to have a high potential for off-label use in ADHD and ASDs.

[absent_]

Lol this dude is straight up Love the honesty :D

[PicassoPrime]

+Sons of Apollo I am going to agree and disagree with you in the same breath so bear with me. While all the scientific explanations do make sense, I do believe from the standpoint of what I studied through college and what is put into practice, that results can vary. I have observed and experienced results from different approaches to supplements/ exercise methods/ etc. that have no scientific backing as well as putting science into play as well. I believe the marriage of the two makes the best data out there. When it comes to modafinil specifically I do believe it is a smart drug for 99% of people out there. I say this because if you think about what you are saying that is -- that modafinil helps people with lowered brain functions to perform better -- then I believe it will still be a smart drug for everyone. With all the environmental factors, altered food supply and a general lack of the perfect set up for our bodies and brains to get everything they need to function at 100% then I believe we can all be helped.

Let me simplify with this thought. Science is amazing for creating content that we can use to further progress in any field. However any hypothesis can only be studied by foundations of assumptions. Something has to be assumed to be true to test something else. A perfect example would be Newtons laws of physics!

[RobertJBarnes]

So, if you found that modafinil helpful with studying, something like Vyvance might knock my socks off?

[trojanhell]

You a 100% wrong it has ADHD benefits I’ve tried it . It makes you focus on your task without break in concentration