Omics Technologies in Target Selection and Drug Discovery Process - Dr Uday Saxena

Topics Discussed
-Introduction to drug discovery - drug discovery is a long, time consuming, expensive process
-Starts with target selection - eg tau for alzheimer’s - 99% targets are proteins
-Omics and disease biology help in the process - important to have a very strong understanding of diseases - Omics play an important role in every step of drug discovery
-Proteomic play a critical role - drug target identification + lead discovery and optimization (molecular docking) + in vitro and in vivo studies (drug toxicity and efficacy) + biomarkers (clinical trials)
-Protein targets - enzymes, structural proteins, receptor, and transcription factor
-Target selection - single protein, associated directly with causing disease, preferable only expressed in disease organ, preferable to inhibit function, cell surface proteins are great targets
-Most drug interact with a protein target

About Dr. Uday Saxena
Dr. Uday Saxena is currently a Co-Founder of the start-up Biotech Company, ReaGene Innovations. He has held Executive and Leadership positions at Parke-Davisin Ann Arbor, AtheroGenics in Atlanta (VP Drug Discovery), Dr.Reddy’s Laboratories(Chief Scientific Officer, US, and India), and Kareus Therapeutics (CEO). He has a Ph.D. in Biochemistry from Memorial University and Post-doctoral training at Columbia University. He was associated with the Team at Parke-Davis/ Pfizer that discovered Lipitor/atorvastatin, the largest selling(peak sales of $17 billion dollars) drug in the pharma business. He led teams that brought several drug candidates from an idea into the clinic.

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