Stroke and death after Moderna

Fatal Post COVID mRNA-Vaccine Associated Cerebral Ischemia

Keywords: COVID-19; Moderna vaccine; cerebral edema; neurology; stroke.

McMillan N, Rosenberg HJ, Anderson MP, Pal P, Stephenson K, Fehnel CR. Fatal Post COVID mRNA-Vaccine Associated Cerebral Ischemia. Neurohospitalist. 2023 Apr;13(2):156-158. doi: 10.1177/19418744221136898. Epub 2022 Dec 5. PMID: 37064937; PMCID: PMC10091442.

Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background

Venous thromboses have been linked to several COVID-19 vaccines

Here we describe a case of post-Moderna COVID-19 vaccination arterial infarct,

with vaccine-associated diffuse cortical edema,

that was complicated by refractory intracranial hypertension.

Case summary

24 hrs after receiving her first dose of the Moderna COVID-19 vaccine,

a 30-year-old female developed severe headache.

Three weeks later she was admitted with subacute headache and confusion.

Imaging initially showed scattered cortical thrombosis with an elevated opening pressure on lumbar puncture.

An external ventricular drain was placed,

but she continued to have elevated intracranial pressure.

Ultimately, she required a hemicraniectomy,
but intractable cerebral edema resulted in her death.

Pathology was consistent with thrombosis and associated inflammatory response.

Conclusion

Though correlational, her medical team surmised that the mRNA vaccine may have contributed to this presentation.

The side effects of COVID-19 infection and vaccination are still incompletely understood.

Though complications are rare, clinicians should be aware of presentations like this one.

More information

Had prior asymptomatic COVID-19 infection three months earlier

24-hours after first dose of the mRNA COVID-19 vaccine (Moderna).

Developed severe, atypical throbbing bi-frontal headache

Headaches were atypical

(no prior headaches)

Three weeks after vaccination

Developed blurred vision and confusion

Bifrontal headache with photophobia

Lumbar puncture revealed lymphocytosis

Broad spectrum antimicrobial coverage was started.

Her mental status acutely worsened later that evening

New left hemiparesis.

Elevated D-dimer

CSF cultures and PCR testing returned negative

Intracranial pressure remained refractory to maximal medical management,

including deep sedation, paralysis and hypothermia,

prompting a right decompressive hemicraniectomy.

The patient expired from refractory cerebral edema.

Brain autopsy showed infiltrates of CD8 and CD4-positive T-cells,

in association with intravascular thrombi

Fungal and bacterial stains were negative.

Discussion

Diffuse endothelial damage and vessel wall inflammation,

suggested an underlying pro-thrombotic state and T cell inflammatory response.

The arterial infarct in this case is likely related to a pro-thrombotic state

Due to the large volume of infarction, the patient was not started on anticoagulation after extensive discussion of the risks vs potential benefit.

In summary, administration of COVID-19 vaccine was considered a possible cause of the extensive multifocal arterial thromboses with associated inflammatory response and elevated intracranial pressure given the temporal association.

The mechanism for initial elevation in intracranial pressure is not known but may relate to cerebral autoregulatory changes in the setting of cortical microvascular thrombosis.

Suspected Unexpected Serious Adverse Reaction (SUSAR) such as this would have put a pause on the entire study and an investigation into why this happened and a call for risk mitigation measures to prevent the same complication from happening to more subjects.

[ZENIGMATV]

I haven’t trusted the government for years but now I despise it.

[garyweston]

We are the carbon they seek to reduce.

[KittyBootie]

When I was asked by my gynecologist if I had taken the Covid jab, I said I didn’t think it would be a good idea based on my having Factor-5 clotting disorder. She proceeded to tell me my chance of a blood clot was much greater if I caught Covid. I said no thanks and haven’t been back to her in 3 years. I’m done with doctors unless I break a bone.

[daveb]

A lot of people need to be in prison over this scam.

[hipnicity]

I am SO GRATEFUL that I said “no” to big pharma!

[ret]

Fauci, Bill Gates. WHO, all need to be held accountable.

[tishbowman]

Without full disclosure they forced people to participate in a clinical trial without their consent. That's horrific.

[richardpoore]

The great awakening is when the world realizes that we are ruled by an evil cabal

[mikedawson]

May the Dr Frankensteins of big pharma get their justice.

[hollowskull]

I just found out a friend had a heart attack and his wife had a stroke. They're both 45 and otherwise healthy. What the actual F!

[DavidPriller]

Both of my parents bought into it and took it. They both passed away three weeks from each other a year later, heart attack and stroke. I didn’t take it and they shunned me for it. Rip mom & dad

[yucafries]

The millions of doctors who violated their patient’s right to informed consent should immediately quit. We don’t need liars to poison us

[tiffanyburson]

When I refused the Covid vax my primary care doctor said I should stop listening to “fringe medicine” & that I was endangering my health!

[dannyhendy]

How it started: Safe and effective
How it's going: Heart attacks and strokes in children have always been normal.

[omagosh]

Im reading these comments with tears in my eyes. I didnt take the jab. I've never had a shot in my life and I'm 74 years old. I thank my parents for teaching me to take responsibility for my health.

[valerielongmore]

Ill never trust drugs or goverments ever again.

[tooletime]

My sister was 39 years old and days after she took her first jab she complained of headache and neck pain. A few weeks went by and she took the second jab, 2 days after she had a massive stroke in the shower. 39 years old healthy mother of two. She fought so hard for her life but after brain surgery it was just too much and she passed away. Rip Jennifer, I love you forever. For those of you that have similar things happen to your family just know that you are not alone.

[Velvetfarmer]

I will write this as many times as I need to. My stepfather had his first AZ on Feb 5th 2021. He died suddenly 27th March 2021. Thrombocytopenia and a heart attack. My father died within 6 weeks of his AZ August 2021. My daughter, 24years old, died suddenly heart failure in March 2023. She had 3 Pfizer’s. No previous heart issues. She just dropped, one day, dead. I’ve lost so many friends to turbo cancers - diagnosis (grade 4 ) to death in only 1-2 weeks and so many strokes, also as a sudden death, and everyone around me is now sick. My world has been destroyed, and continues to do so. I really live day to day now.

[lynnedavis]

A lot of people feel that these demons should be held accountable . But when is it going to happen.

[bookgal]

My beautiful husband had two Moderna, even though I begged him not to. He is no longer with us after suffering a debilitating stroke. He suffered in terrible terrible pain for 10 days in the hospital… it was an extremely horrible death. The neurologists could find no reason for him to have had a stroke… well, I know why. Our family is so heartbroken to have lost him… he was such a beautiful soul. I don’t think I’ll ever feel happy again.