The brain and obesity | The Royal Society

The Croonian Medal and Lecture 2022 given by Sir Stephen O'Rahilly FMedSci FRS and Professor Sadaf Farooqi FMedSci FRS.

#obesity #weight #health #food

Globally, over 1 billion people are overweight or obese. Obesity and its complications are associated with significant morbidity and mortality due to type 2 diabetes, cardiovascular disease and some forms of cancer. While the widespread availability of high calorie, palatable food and physical inactivity are major environmental drivers of the rise in prevalence of obesity, heritable factors play a substantial role in influencing a person’s propensity to gain weight (or not), within an obesogenic environment.

In this lecture, Professors O’Rahilly and Farooqi will discuss how the identification of genes and the pathways they regulate has highlighted the fundamental role of the brain in modulating eating behaviour and body weight. They will discuss how studies of the leptin-melanocortin pathway have provided a mechanistic framework for understanding how body weight is regulated in humans, how energy status is coupled to reproduction and growth and how disruption of these neural mechanisms causes obesity. They will also discuss the impact of this work on societal perceptions of obesity and how targeting these mechanisms has provided new treatments for people with severe obesity.

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[Stop-and-listen]

Extremely informative. I will be contacting the GOOS for further information on BBS.

[christopherscobie]

Lets have a two week lockdown, sorry two year panic/global pandemic mania over obesity, it kills a lot of people everywhere. worse that a virus i'd say.. Great talk, much obliged, so interesting.

[applegal]

In my extended family, women who have a larger waist and smaller hips have diabetes, and ones that have larger hips and smaller waists have none. Thank goodness I didn't inherit a small hips and bigger belly from my mom. I got the Hooper hips...from the ancestors who had big arses in our family lol The only down side is to find pants that fit properly in both hips and waist.

Genetics definitely has some role in our body size and predisposes people to different diseases.

In saying that, I'd be obese if I didn't control my food or exercise. I used to be obese many years ago caused by mental and physical issues. Thankfully I have knowledge about human health and am financially able to afford healthy food, and have the time to cook at home and exercise.

[voidisyinyangvoidisyinyang]

fascinating that obesity is inheritable!

[maxwelldillon]

Fantastic work. You already know that there will be some people who will outright deny these findings and stick to their ridiculous ideas of 'free choice'. Oh well, I guess they're determined to be that way. I wonder about the mechanisms underpinning their stubborn science denial...

[funkymunky]

is obesity inheritable by 40-70%? Because i have found other sources in the web which says it is inherited by maximum of 5% ?

[rezalayeghi]

The genteman, one of the speakers may be great idea that he looks at BMI . please

[Exodus.Pi]

I ate like an American and got to 400. Now I eat like a wealthy peasant in the 1800s minus the sugar.

[TheDavidlloydjones]

At 12:09 there is a reference to "gavage feeding, "* I think it is. I don't know the term. I'm not sure what the word is or how it's speled, so I went back and looked, twice, at the written captions. It's not there. Whoever typed up the dot-srt file didn't know what the word was, so they simply left it out. I.e. they took the money but they didn't do the work.
This is shameful. Somebody should be fired.
Somebody else should be fired, get the work done, and replace the file here on YouTube.

* Apparently the word is "gavage." It means feeding through a tube. If I can look it up, the person paid to do the job could have done so, too.

[rezalayeghi]

The main cause of obesity is Insulin Resistance. The cause of it is the SAD diet which encourage carb diet. Please have a look at Dr. Jason Fungs's work and Ketgenic diet plus fasting. I hope you will come up with great new finding.

[overtsaceie]

Very informative but it is hard to understand an old man repetitive speaking

[danielrodgers]

Congrats, sounds like in another 40 years you guys will discover that if humans eat Real food and exercise then they won't get fat and sick.