20. Human Genetics, SNPs, and Genome Wide Associate Studies

MIT 7.91J Foundations of Computational and Systems Biology, Spring 2014
Instructor: David Gifford

This lecture by Prof. David Gifford is on human genetics. He covers how scientists discover variation in the human genome. He discusses how to prioritize variants based on their importance. And then covers how to prove causation, not just correlation.

License: Creative Commons BY-NC-SA

[ginaortiz]

hands down one of the best lectures I've ever seen about this. Absolutely incredible, and surprisingly accessible.

[ElNick]

A truly well-delivered lecture is a beautiful thing to behold.

[raznas]

Been looking for a good video that can give me an overview of GWAS. This is great. Thank you.

[Msgoodwawa]

A beautiful lecture, this helped me a lot in GWAS background study.

[songthanh]

A beautiful lecture that helps me learn a lot, thank you very much professor!

[learningaboutscience]

I feel bad because the class is very unresponsive to the point where the teacher starts to disengage about 20 minutes in. At which point the lecturer and the students lose a connection (my hypothesis), and he starts to doubt how interested everyone is. We appreciate you Mr David Gifford, don't ever forget that! Always believe in yourself and don't let the dulled minds of the mob get you down!

[JCResDoc]

1:14:03 Association Variant Pedigrees (enhancers & mutating NSP position tests to elucidate promoter of gene proper) [causality claims of fctn]

[danielparker]

Whoever spoke up at ~54:18 --- plz be my friend

[JCResDoc]

19:15 Polygenetics (maybe, nearly, w/no follow up replication or Tx/Rx) comes up w/the win for 50& genetic loading for associated risk, maybe probably.

[JCResDoc]

32:44 In recessive illness, taking out primary in x+y line = bad news [phasing of varience]

[nibussss]

I have a theory that onc u start losing a slippery slope...brain areas deactivat...less sleep needed....less of several functioning

[MrKasshiff]

I have a question which I am unable to find in published papers. Does a small term or long term stress (any kind of) could introduce SNPs in an individual (or any species)?

[JCResDoc]

1:16:30 Ident twins studies show no great personal genome med promise in path, nor risk reduction in neg findings. <3

[JCResDoc]

1:15:38 monozygo twins brawl starter in genetics bars

[JCResDoc]

57:25 assuming independant reads, eq from ma/da (Haplo lily pi fcnt)[Bayes Inf]

[mindlessgreen]

Does anyone know where the plot at 30:00 is from? I can't seem to find it anywhere.

[JCResDoc]

4:13 A lot of correlational gobbledegook, given the claims that some corners of this field keep making - that lead no where

[JCResDoc]

12:20 this is why genetic research never leads anywhere.

[via]

The person who opened a can at the beginning is kinda rude.