K Ray Chaudhuri, EAN 2019 – The spectrum of wearing-OFF: non-motor features

European editorial board member K Ray Chaudhuri (King’s College and King’s College Hospital, London, UK) discusses the topic of his Bial-sponsored satellite symposium presentation entitled – The spectrum of wearing-OFF: non-motor features.

Questions
1. What are the most impactful non-motor symptoms that you would expect to see during OFF state in patients receiving dopaminergic therapy? (0:12)
2. Do these non-motor symptoms occur in the ON state with the same severity? (1:09)
3. Are these symptoms present consistently or do they vary during different stages of the disease? (2:09)
4. How impactful are these non-motor symptoms on a patient’s daily activities and quality of life? (2:54)
5. How important is an accurate and early diagnosis of wearing-OFF and what tools are available to help physicians? (3:32)

Speaker disclosure: K Ray Chaudhuri has participated on scientific advisory boards and/or received honoraria for scientific advice/lectures from AbbVie, Bial, Boehringer-Ingelheim, Britannia Pharmaceuticals, Cynapsus, GKC, Jazz Pharma, Lobsor, Medtronic, Mundipharma, Novartis, NeuroDerm, Profile Pharma, Pfizer, Stada, Sunovion, UCB and Zambon. He has received grants (investigator-initiated) from Britannia, AbbVie, UCB, GKC and Bial; and academic grants from: EU, IMI EU, Horizon 2020, Parkinson's UK, NIHR, PDNMG, Kirby Laing Foundation, NPF and MRC.

Filmed at the 5th Congress of the European Academy of Neurology (EAN), Oslo, Norway, June 2019, with support from Bial.