AHS12 Chris Masterjohn — Oxidative Stress & Carbohydrate Intolerance: An Ancestral Perspective

Chris Masterjohn, Ph.D. has just completed his Ph.D. at the University of Connecticut, where his doctoral research focused on the role of oxidative stress in regulating metabolism of methylglyoxal, a major precursor of advanced glycation end products. He created and maintains Cholesterol-And-Health.Com, where he publishes his blog, The Daily Lipid.

Abstract:
The role of carbohydrate in health and disease remains controversial in the ancestral health community. Numerous groups of foragers, pastoralists, and agriculturalists have been found free of the so-called "diseases of civilization" while subsisting on diets rich in carbohydrate, yet clinical trials have shown that low-carbohydrate diets can help reduce disease risk in modernized populations. In this talk I will discuss evidence from my doctoral research suggesting that oxidative stress contributes to carbohydrate intolerance and will review the literature suggesting that oxidative stress is a common cause underlying carbohydrate intolerance in modernized populations. I will conclude by presenting a broad, holistic view of "oxidative stress" that moves beyond "antioxidants" and focuses instead on the density and balance of nutrients in the diet, and the optimization of the hormonal milieu within which those nutrients operate.

[gilgamecha]

This is a really thought provoking talk. I think I need to watch it again. There is so much in there. An explanation for insulin resistance that isn't just a 'black box'. A possible etiology for beta cell loss in Type 2 diabetes. And all kinds of suggestive interventions. Wow. This guy is good!

[howzaou]

I've been watching these presentations for the last two years and I really wish they would make these Q & A sessions more robust.  Seems like they are always rushed and people are running around randomly and making noise.  Whoever organizes these please make it a law that 15 whole minutes is dedicated to just Q & A, no exceptions!  And tell the damn audience to sit tight and shut up while questions are being is the most informative part of the talk.

[nickb]

So eating polyunsaturated fats along with carbs will likely result in getting fat

[jillbetts]

What an excellent information packed talk. Thank you Chris and Ancestry foundation

[LLLACor]

Very PHD level! I thought Dr Lustig was academic enough but this! Even after reading the abstract above, I am still not sure about Dr M's conclusion, or at least opinions, about what the title suggests. Maybe more of his personal suggested application from his research to day-to-day human society? This feels like a rabbit hole albeit great presentation! Thanks for being a pioneer in our ever refined micro-medical-biology.

[Vahe]

Wow thanks for this great video. So much serious science. I learned a lot. I just hope Dr. Masterjohn  makes more lectures on diet and how it relates to function of the body and disease. Hopefully one soon about thyroid function:) anyone know any good diet thyroid function lectures/videos?

[precisionmedicine]

It is about a balance between hormesis and antioxidation. These are the two sides of the pendulum around which human health rotates.

[dawnfyler]

This information is detailed and very interesting, especially in terms of a clear explanation of some of the cellular signalling leading to insulin resistance. Also, the role of anti oxidants and oxidants in the role of cellular signalling in regards to energy storage and overload.

[KeithWWallin]

Makes you wonder if an increase in Catylase and Super Oxide Dismutase (SOD) thereby increasing the production of Glutathione, would be beneficial to reducing oxidative stress and lowering the amount of low level inflammation in adipose tissue. Seemingly, this would result in an increase of insulin sensitivity and a decrease in fat storage. Interesting!!

[maid]

Hi,

Just wondering if Chris will be coming to Toronto at any time? Also, what does Chris eat? He speaks a lot about how we all have individual nutritional needs, however, is there some sort of starting point for those of us who are not researchers, and just looking to eat a healthier diet?

[justaddmusclecom]

So much Science in one awesome video. This channel is worth gold.

[davidlomm]

Soooo, ... Glucose Intolerance, ... Starch Intolerance, ...
Just, ... Eat a Low Starch, No Grain diet rich in good proteins, good fats & antioxidants from vegetables & you are all set, ... Sweet :)

[MultiMusik]

how about allergic in chicken, seafoods and shrimp paste?

[ideoformsun]

If the mitochondria become damaged or are dead, then the ability of the cells to utilize energy would be reduced.
Certain pesticide residues in foods, particularly grains, and seeds that are used to make oils, could be damaging to mitochondria, since the mitochondria are bacteria that have evolved with us in a symbiotic relationship.
Concentrating these foods into products like various flours and oils also concentrates the contaminants.

[eileenlang]

So im studying and he pops up- this is my professor haha

[Bass.Player]

I can see this however, increased blood insulin levels have been observed when glucose is liberated in the reduction of adipose tissue. So it would be difficult of observe behind that mask...

[eggtricks]

Oh, so Jerry Seinfeld has a rebellious son who went in to medicine! He's great at stage, too :)

[tnvol]

I have a large number of older Asian friends, ages from 80-99 mostly from China.They eat a diet of about 80-90% ordinary white rice.Every one of them are healthy, vital, and active.So carbs cant be too bad.

[ralfoxygen]

Reduce Oxidative Stress ("Free Radicals") with Vital Air 5+ device !

[MrJaaaaake]

If we are meant to eat carbs why does it rot our teeth so fast? Go on a raw food diet from 0-25 and you'll be missing most of your teeth by then making it hard to eat.