Medical Mystery Solved – A Diagnostic Sequence | NEJM

This Double Take video from the New England Journal of Medicine presents the case
of a 42-year-old woman presenting with cough, fatigue, fevers, and shortness of
breath. Based on a Clinical Problem-Solving article published in the Journal, the
video explores the differential diagnosis for shortness of breath and highlights
the importance of maintaining a broad differential when first-line therapies fail
to improve a patient’s condition.

The New England Journal of Medicine is the world’s leading general medical
journal. Continuously published for over 200 years, the Journal publishes
peer-reviewed research along with interactive clinical content for physicians,
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#medicaleducation #clinicalmedicine #nejm #doubletake #clinicalproblemsolving #diagnosticevaluation #emergencymedicine #differentialdiagnosis

[MyPerennial]

Great case, beautifully presented, unfortunate ending for her, yet it impels us to always strive to improve, to help our next patient...

[sNazzy_nazzy]

This was truly amazing and educational to someone outside of the medical profession. Thank you for the work you do! It makes crucial information accessible to members of the public like me.

[simongeisker]

This is fantastic content. Thank you for releasing this to the public, so provides at all levels of training can continue to educate themselves.

[doctormai]

Hope you make more similar and useful videos to help more people.

[DrChirath]

Excellent analysis of the clinical case! Thank you NEJM team!

[Matthew-kyit]

Wow excellent narration and graphics. Going through cases like this is such a great way to teach. Although I'm sure it put a ton of work to put together ❤

[naywin]

Nice one. If a patient with bronchiectasis and high blood sugar it is prudent to consider cystic fibrosis in low income scenario.

[KhouasDehbia]

thank you very much NEJM for this
it was really fun to watch and very informative

[ToxicCoworker]

Excellent breakdown - CF has a long road to the foreground in adult medicine with Trikafta's game-changing efficacy in some patients. I'm doubtful of how well peds facilities will keep up with a growing population of older patients (thankfully due to longer, healthier lives).

[SerafimMoreno]

Subject matter Very interesting and top great video

[katelynpanos]

Maybe useful to note what ED docs would see to catch mild CF/atypical/cftr related disorder before this outcome. My journey to mild CF diagnosis was....stupid. I needed the aid of my genetic training, my veterinarian friends and my connections at my former job to be assessed for CF despite multiple hospitalisations for shortness of breath resistant to albuterol and metabolic symptoms. I would BE her if I didnt happen to work in genetics and my friends werent trained in vet med.

[wvsteadman]

I think it is important to note that the genetic modification medications mentioned at the end of the video, were created based on 90% of the genetic mutations found in CF patients. It was a statistically based decision, to create drugs that treat the most common variant in the US>

[slmslm]

Thanks. Unfortunately bad end for the patient

[tindrums]

was thinking dormant TB or Allergens in the beginning.

[shaazhaidar]

suspecting cystic fibrosis in a 42 year old chinese woman would be so down the list of things you would do...such a rare case which was fatal for the patient

[Adsd]

It’s so hard to fight nature and keep patients alive. As a physician who works in the hospital there is an assumption we will be able fix everyone and everything putting immense pressure and to some extent burnout. Science and technology might not fix everything

[sureshmanickavel]

microbial cell-free DNA blood tes, in this particular case, could have identified the pathogen 1-2 weeks earlier and it might have had a strong favorable impact on the course.

[ChaiJung]

What are the exact prevalences of each mutation by race?

[EtheralV-szdt]

I learned a daunting truth when it comes to the American doctor's negligence with parasitic infections, and it is baffling.
When labwork is done, the physian does not receive the full scope of the lab results like the patient can see in their patient portal. I just discovered this and have proof. But who do I tell that could do something about it?