ARNI: sacubitril/valsartan. Mechanism of action, dosage, indications, side effects

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ARNI (Angiotensin II Receptor Blockers Neprilysin Inhibitors) is new drug class that is used for treatment of the heart failure with reduced ejection fraction. Nowadays, this drug class includes combination of sacubitril and valsartan.
Mechanism of action, side effects, dosage, drugs interactions and more see in this video.
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Great explanation!!! Profound and to the point, very informative, thanks!!🍭🍬

adela
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Thank you so much for great explanation. Blessings!

emydan
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Why instead of Valsartan is not used with Sacubitril?

sitanshubhattacharjee
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Meant to say, he did not have ventricular arrhythmia prior to Jan which is when he began the Entresto. Every day is worse than day before. We don’t know if it’s best to change cardiologists (I know several and we have a Heart Hospital) but we have to just “start over “ is what I get when I call to ask clinics. It’s as if we’re stuck in a special kind of hell that should never be.

liztripp
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sacubitril decreases aldosterone ...so why to add valsartan?

nsas
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Why combination & why
So Expesive: Alone for
Ht failure why not

ibrahimelgendy
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My moms sodium came down.. blood pressure came down.. she started vomitting .. after taking this medicine.. later norad was given to raise her blood pressure which resulted in heart rate to 120.. which created VT episode twice... Second time she couldn't be saved... I am still researching on this drug.. pls connect if u hve more info.. thanks

udlovemusic
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