Intellia base editing?! 🤷🏻‍♂️ What?!! | NTLA (stock)

🎦 summary ⌲ News of Intellia base editing was press released recently. This is strictly in the domain of BEAM therapeutics. I will examine their claims in a greater detail and offer my views but before that, it is pertinent to dissect the history of the animosity between the different CRISPR companies.

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00:00 Summary intro
00:25 History of CRISPR-Cas technology
02:23 How the disputes started
04:44 My personal thoughts about the situation
05:20 The dispute that continues to this day
05:54 History of base editing
06:18 More drama, the Intellia base editing announcement
07:40 My thoughts about Intellia base editing
07:57 For the watch till the end gang

Audio credits ⌲ The white fox, StreamBeats by Harris Heller
Disclosure ⌲ BYang is long (and own) BEAM and ILMN stock

[benperschau]

Excellent video as usual Benjamin. This really vexed me when I heard this news, and I am anxious to see how this plays out.

[lindseyreese]

Without an editor, Cas9 may be used only in deletions and disruption once base editing establishes itself.
Only 1 cut, easier and better targeting and being able to potentially modify 4 genes or more at a time to attack more diseases is an advantage.
Editas will probably license Beams Editor at some point or perhaps a next generation, better one that's likely in a private lab somewhere.
Beam licensed Editas Cas9 and other tech before it's IPO. The Royalties are unclear. I asked Investor relations and they said they couldn't tell me!
PKI has said since January of 1/2020 in press releases, reports etc that they will license the Rutgers editor. But they've never announced a sale.
I think it would take a lot of time and research to catch up with Beam.
But certainly BEAM is not alone and no guarantee to dominate.

[SimplyAnnaBanana]

keep up the amazing Bio/investment classes, wish u a lot of success !

[SimonSonderskov]

Hi Benjamin
Great content.
Could you explain the topic of DNA silencing using RNAi as used by Dicerna?
My understanding is that it's a little more mature method than CRISPR?

[emilythorne]

Very disappointing to see that NTLA is using base editor without citing Beam.

[nomiji]

Awesome! I like the way you told the story. So which side of the history are you on? BEAM/EDIT or CRSP/NTLA? :)