TWiV 799: A very model of a modern TWiV

TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens.

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Twitter: @profvrr

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I’m Vincent Racaniello, Earth’s Virology Professor.

I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this YouTube channel I share videos of my lectures, podcasts, and more.

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#microbe #viruses #coronavirus #pandemic
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[MrOzzyCam]

Thanks Vincent and TWiV team for another show! Always look forward to these!

[johnbouttell]

Hi Vincent, I'm very excited about your live YouTube course. Best wishes, John in the UK. PS Your talk with Lex was great.

[CA-qwpi]

I also grew up around the same time as Kathy, and I remember "Sabin Sundays". The family attended church services and afterwards marched next door to the school auditorium and got our vaccine on a sugar cube. Good times...

[anatolyl]

39:14 When you start at 70% or at 95%: Actually while 70% and 95% look close in numbers there is a huge difference. 95% effectiveness is 1 to 20 ratio (vaccinated to non vaccinated) while 70% is 1 to 3 something ratio.

[nxjitki]

You guys ( n gals ) are fabulous! Bril clarity from Rich. Those correlates of protection. Thanks on the immunology Brianne.

[ianpollard]

Also here from Lex. Thanks so much. I needed to hear from you long ago.

[anatolyl]

35:41 If they say the efficacy after 250 days should be 77% - the model is not correct or maybe outdated. The data from Israel (severe cases the efficacy is 60-65% after 6 months and declines further after that) and UK has similar numbers.

[MrOzzyCam]

I am in Australia and will be up for whenever you do a course Vincent!

[christopherrobinson]

Rich: Easy Choice get vaccinated or not.

Not. High probability of a bad outcome.

Vaccinated: Low risk of adverse effects, good protection against serious disease and death.

Darwinian selection does not only apply to the virus, but also to the host.

[eliseleonard]

It is a joy to hear you guys have fun reviewing good work (the FKrammer paper) - it’s got to be more fun than railing against crazy talk.

[MrOzzyCam]

Ross River Virus emerged from a relatively remote rural location in Australia. It has been moving south but is an infection of the more tropical north.

[presidentresident]

Random question to anyone that can answer: what defines actual 'infection'? In other words as your body is encountering viruses, what is the threshold reached at which time a person is considered infected. Is infection technically at the stage that one of your cells is breached and actually replicating viruses? Or is it something more amorphous and hard to define?

[patriciahoke]

So glad Shane Crotty is returning soon!!

[traiandanciu]

At TWiV 714 at min30 Amy indicate a study about different proportion of antinucleocapside antibody at children (Farber study?)
Can that explain or be corelate with severe disease?

[rhonawill]

How can we almost be at Episode 800? Wow keep it up.

[gerardbiddle]

This TWiV #799 has been very interesting and a very informative discussion. Thank you all. A very very model of a modern TWiV - Major General HMS Pinafore. I am a Gilbert and Sullivan Operetta fan! 🧐🤔😆

[lampanish]

are there any indicators that a person will be asymptomatic to SarsCovi2, or is it just a random thing with any virus?

[traiandanciu]

How many epithope have SARS COV2?
Which of them can induce cros reactivity with human cells?
Which of them can induce low temperature aglutinine?
Can Spike vaccination decrease some other SARS COV2 antybody?

[elbodegondelascebollas]

i'm in mexico and Iĺl love to attend the course :D

[ScotHarkins]

I would imagine the host that is most likely to carry a virus to an unprotected population would win the day. Humans love to travel all over the place in any given region.