Doctor explains ALS in 60 seconds #ALS #Neuroscience

🩺Diagnosis:
- Amyotrophic Lateral Sclerosis / Lou Gehrig's disease / ALS

🔍Risk Factors/ Pathophysiology :
- Epigenetic: Military Vets have a 2x higher risk of contracting ALS
- Genetic/ inherited
- Errors in protein transport & Recycling ➡️ protein accumulation ➡️mitochondrial damage ➡️ breaks in 🧬
- Poor 🧬 repair = ☠️ of the neuron
- Cell transport ⚙️ damaged ➡️ issues with neurotransmitter messaging
- Damage to the cytoskeleton ➡️ axonal retraction ➡️ disconnection of nerves & muscles
- Oligodendrcyte damage & ⬇️ uptake of neurotransmitters ➡️ 💀
- Neuro-inflammation

🕵🏼‍♂️Differential Diagnosis:
- Multifocal motor neuropathy
- Cervical radiculomyelopathy
- Benign fasciculations
- Inflammatory myopathies
- Post-polio syndrome
- Monomelic amyotrophy
- Hereditary spastic paraplegia
- Spinobulbar muscular atrophy
- Myasthenia gravis
- Hyperthyroidism

🧪🩻Diagnostics:
- Electromyography (EMG)
- Nerve conduction studies
- Brain MRI
- Neuromuscular ultrasound +/- muscle biopsy
- LP for CSF analysis testing
- Urinalysis with culture +/- UPEP, CBC w/ diff, CMP, TSH, CK, ESR, ANA, RF, B12, anti-GM1, HIV
- Genetic tests: C9orf72, SOD1, TARDBP, FUS, and UBQLN2

💊 Treatment:
- Riluzole
- Edaravone
- Tofersen (Qalsody)
- Symptomatic management

#medicalstudent #medicaleducation #usmle

[destinyneal]

ALS is a horrific disease. I lost someone to it and I wouldn’t wish it upon ANYONE.

[JJNow-ggso]

Where were you when I had to learn all this?
Learned something new that ALS has been DIAG twice as much in servicemen.
THANKS....

[shellydesormier]

I contracted botulism 10 years ago and had many of the same symptoms, including paralysis for 2 1/2 months. I had to re-learn how to use all of my muscles again and still have permanent nerve damage. It’s was a terrifying experience.

[LauraFunFunFloweries]

I am a, military vet, so why are soldiers, more likely to develop, ALS?

[audiophile]

DUDE, SLOW DOWN!!! If i have to replay the end of the video 8 times to understand what you said is just frustrating enough to make me not want to "like& subscribe"... or even watch.

[SCG_]

This is the desease that killed Stephen Hillenburg 😢

[enbaris]

Do you really expects us to understand your fast speech?

[mdrahullamin]

I am a Bangladeshi soldier, where can I get good treatment for this problem of my firing ring

[Busted.Knuckles.Garage]

Why dose your channel and 98% of all the other ones put so much text on the screen, One can't even see the video, that you guys/gals spent all that time to create, isn't the "Video" the key to all this info., your trying to educate people with. I'm a person as do many other learn better from watching and learning from visual effects not by reading untill I fall asleep, so if your hurting for subscribers we'll that is where your problem is, The biggest reason why YouTube has exploded over the last 10 yrs, is because of people would rather watch a video than read, so enough is enough I'm dumping your channel, plus all your social media accounts. If thing change I'll look back into it as soon as u start Losing even more subscribers Have The Best Day's Possible from All of Us at Questionable•Goodz74