Vit D and prostate cancer

Circulating vitamin D level and mortality in prostate cancer patients: a dose–response meta-analysis

Results

Higher vitamin D level could reduce the risk of death among prostate cancer patients.

Association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer

We conducted a dose-response meta-analysis

Seven eligible cohort studies, n = 7, 808

The summary HR of prostate cancer-specific mortality

An increment of every 20 nmol/L in circulating
vitamin D,

(20 nmol/L = 8 ng/ml)

HR = 0.91, (P = 0.002)

Every 20 nmol/L increment in 25-hydroxyvitamin D level was associated with a 9% lower risk of,

all-cause mortality,

and prostate cancer-specific mortality.

Pooled HRs were stable and not obviously changed by any single study.

No evidence of publications bias was observed.

This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients,

and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.

Risk estimates with 95% CI for the association between 25(OH)D and prostate cancer-specific mortality.

Mechanism

Vit D, could cause cell cycle arrest,

and induce apoptosis,

inhibiting cell proliferation in several prostate cancer cell lines

Protection from prostate epithelial cell lines from oxidative stress

Will supplements help?

Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial

4,000 units (100 micrograms) day

24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score

Prostate cancer in black Americans

Cancer prevention

Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer

[finster]

I’m a ten year stage 3 colon cancer survivor. At my oncologist’s recommendation, I’ve been on a vitamin D regimen since my remission in 2014. A side benefit has been a reduction in common colds by around 75-80 percent. I’m a firm believer in this study!

[davidlucas]

A "real" doctor serving his patients and his oath!
What a rare person in these sad times.
Thank you for all you do.

[aliterogasolini]

John, You deserve some form of Award for services to humanity. For going where many others were too afraid to tread.

[alanc]

I have been taking 5000 IU per day for several years. My doctor wanted a PSA reading because of my age and it returned at 0.72. Very pleasing.

[sharonwhiteley]

My husband had prostate cancer and been on Vitamin D ever since.
Thanks for continuing to fight for our health and well-being

[tlevans]

I was diagnosed with Stage IV Prostate Cancer five years ago. Had radiation and 18 months of ADT treatments, but also increases my uptake of D3 to 10k ius and 100mcg of K2. Have recovered very well. So far, the Cancer is in remission and I've not had a cold or repertory illness since taking the D3.

[billmcmeekin]

My coworker got me on D3 and K2 a few years ago. I utilize a Keito diet also, and feel much better. Lost weight, joints feel great, and rarely get sick. 56 and looking forward to a healthier retirement in 60's. Vitamin D is cheap, and benefits everyone in Canada. Cheers Dr Campbell.

[RollingTree]

Just adding a comment to support this channel in the face of YouTube censorship. I prefer to take responsibility to evaluate information on my own, not have select groups paternalistically or authoritatatively filter it for me. I will seek out more of this voice in response, as it has proven more generally rational than the censors.

[zoebowler]

I’ve been a vitamin D pusher since covid hit. I’ve been called all sorts because of my pushing my family and friends to take it. I even buy it for people who I care about. ❤

[khaledbalamash]

Thank you so much Dr.Campbell. I've been taking 5, 000 IU daily for the past 3 months, and I did notice that my food allergy sensitivety is reduced and I feel more energetic overall.

[imsbvs]

My dad suffers with this disease, his dad died from it. I have lymphoma and have been taking high dosage Vit D since the COVID problem started. I am aware it is possible to have two cancers simultaneously, so simple steps like this are very worthwhile for my long term health.

[Nor]

I have been taking Vitamin D supplements for nearly 10 years. Doing this along with a near zero intake of processed foods plus an increased intake of fruits and vegetables has more than helped me to have no need for any form of medication.
I also started taking K2 after watching your videos.

Government policy won’t change because there is no money to be made by the pharmaceuticals if this takes place. The responsibility lies with us as individuals to find this out for ourselves.
Thank you for everything that you do.

[scaldon]

Good afternoon everyone. Please remember to take your Vitamin D. Have a good day 😊.

[MekongRick]

I have been taking Vitamin D3 supplements since I started watching your channel in July 2020. This news about reduction in prostate cancer is a complete surprise and fantastic news for me. I was successfully treated for prostate cancer in 2014. It does not mean immunity forever, however. Just being realistic. The last time, I tested 41.5 ng/ml (x 2.5 = about 103 nmo/L ) for Vit D3 at the end of December 2021. I will keep up this Vitamin D3 intake (and added K2 last year) and increase the dosage, since I was taking a fairly low daily dose of 2500 IUs. I am so thankful for your solid, dependable information. I will be sharing this video post to many friends.

[jf]

Dear Dr. Campbell, you are a modern-day hero! Thank you for your brilliant and transparent dosage of health-related information.

[dr.aculasdad]

Just to reassure anyone recently diagnosed with Prostate cancer, it is NOT a death sentence !
On initial diagnosis, I became very depressed, and contemplated taking an "easy way out"

I am 78, and had diagnosis in 2002, radiation in 2003, my current PSA is 15.3 - the same as it was three months ago. The steady increase appears (so far) halted, or, so I hope !
I started taking 2000IU of Vits B1, B12, C, D, plus Spirulina toward the start of the last couple of years (guess why !), have had no colds, and the stabilisation of my PSA.
I have normally taken Vit D, but, over the last three months, had Vit D3 - coincidentally!
Good Luck to any Men out there, battling or freshly diagnosed, you are not alone, there IS Hope and Future.
Just imagine missing out on your Grandchildren - as I so nearly did !

[bfisk]

I started taking vitamin D 3 years ago after Joe Rogan had a doctor on his podcast explaining how important it was for you to take vitamin D. This was also at the start of the covid pandemic and I am so glad I started taking it. My health has done a 180 since, it seemed like it woke me up from always being sluggish. If I could make everyone start taking it I would. It really is beneficial!

[scarcasmtincap]

These are the studies the govt should be funding, not supporting big pharma

[wsteele]

I have been taking Vitamin D (5000 IU/day) for the last 25 years. I started it on the recommendation of my very enlightened PCP MD (long since retired). Seemed he was way ahead of his time. No regrets.

[misshoneybee]

Vitamin d and its levels have been a Godsend in saving countless lives in many illnesses and diseases for years, and I am so glad you are talking about it openly. However, some may find this information dangerous and try to silence it. I applaud your bravery and truthfulness doctor and love hearing the updates. Also its why the sun is so important to life.