Close-up of DNA extrusion simulation

Close-up on a single extrusion complex in a computer simulation of DNA extrusion. First, an extrusion complex containing two subunits attaches to DNA, forming a small loop. Next, the two subunits slide along the DNA in opposite directions, while remaining physically tethered, growing the loop. For more information, see

"Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes." Sanborn and Rao et al., PNAS 2015.

Video by Najeeb Tarazi and Adrian Sanborn