FIBROmyxo vs MYXOfibro Sarcoma Made Simple: 5-Minute Pathology Pearls

Soft tissue pathology is filled with "myxo-" and "fibro-" terminology, which makes it even more confusing to beginners. One of the most notorious confusing name pairs is low-grade fibromyxoid sarcoma vs myxofibrosarcoma. They sound similar but are usually very easy to tell apart microscopically. Watch to find out how.

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This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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[vinvinvino]

There is simply no Youtube Pathology trainer like JERAD! Absolutely awesome information always.

[SandhyaRamachandran]

Jerad, your 5 min pearls always leave us wanting to know more, but with a clarity which is sooo helpful. Thanks much for your effort & time!

[buckylasek]

Great presentation. Love the short format, perfect during a coffee break

[trishitabhattacharya]

Amazing concepts Sir..So inspirational! The way you teach is just brilliant..

[InfinitEternaLovEmmanuel]

Excellent, clear, concise! Thank you!

[markzaki]

Very effective this type of short format videos and Put signs on the road, with quick gain of most important tips, if anyone needs more go to long format.

[Josesordo]

Thanks for the precise and concise information about those 2 entities 🙏

[missknowall]

Super excited to see that it is intended to be a series. Looking forward to more and more.

[fahmidasiddika]

Thank you so much. i cant stop watching each and every presentation of yours again and again. Thanks, thanks a lot.

[chandanbajad]

Amazing way to present and make us aware about the crisp vital pointers, thank you...

[ramadanshatwan]

Many thanks Dr Gardner, very nice and helpful video

[AnatomyHelper]

SOOOO helpful! My son was just diagnosed with LGFMS and this helped sort out all the terminology. Thank you so much!
(also, I teach anatomy so the histology was awesome)

[rymahamoudi]

Thank you so much
For me you are the angel of pathology😊😊

[etak]

Absolutely LOVE this video. More please!

[hairyllama]

Clear and concise explanations, thank you.

[zaakouk]

Thank you so much
Really, hope to see more of these short teaching videos

[sridevivijaykumar]

Really well explained... Thank u sir for ur gr

[hiphopunike]

Good summary of the topics... hard to tell that's LGFMS from the pic, looks like a generic fibroblastic/myofibroblastic proliferation.

[SmogDP]

Thanks. I have one in grade two. It will be a difficult path to recover but I can!! Lets fight!

[catanauan-tabletennis-atbp]

Could someone explain the below final pathology report? My friend has done Radio therapy prior to surgery.

Macroscopic description:

Wide resection. An excision of soft tissue 95x75x48mm consisting of fibrofatty tissue and skeletal muscle. The specimen is sectioned from medial-lateral into 14 discrete slices. Located in slices 4-6 and partially slice 7 is a heterogenous circumscribed soft solid mass 36x27x17mm (superior-inferior, medial-lateral, superficial-deep).



Microscopic description:

Sections show skeletal muscle with overlying skin. Within the skeletal muscle there is a circumscribed tumor composed of hyalinised tissue, areas of loose fibroblastic tissue, oedema, haemorrhage and a patchy lymphocytic infiltrate, consistent with treatment effect. Scattered through the tumor nodule there are single epthelioid cells, some multinucleated, with hyperchromatic, pleomorphic nuclei and atypical mitotic figures. Occasional spindle cells with similar nuclear features are also present. these atypical cells are interpreted as residual tumor cells. No tumor necrosis is seen.

The tumor cells are positive for vimentin. there is some patchy staining for sox10, but the tumor cells are negative for s100 and melanA. There is patchy weak to moderate positivity for erg(interpreted to be non-specific reactivity), but the tumor is negative for cd31 and cd34. there is weak reactivity for cd99, interpreted as non-specific reactivity. The tumor is negative for cytokeratins ae1/ae3, cam52, berep4, 24be12, ck5/6, p40, ema and negative for sma, demin, cd34, cd68, and mdm2. there is retained expression of h3k27me3. Overall the features of resected tumor would be consistent with UPS.

Grading of the post-treatment tumor has not been performed due to the scant tumor cells present.



Diagnosis:

Residual tumor cells are present 5mm from the inferior and superior margins and 6mm from the deep margin.

No lymphovascular space invasion or perineural invasion is seen.