Pharmaceutics (24) Biphasic Liquid Dosage Forms | Pharmaceutics 1 | B.Pharmacy 1st Semester

Biphasic Liquid Dosage Form
Biphasic Liquid Dosage Form Contains 2 Phases. This Includes Undissolved Drugs and the Solvent System(Vehicle).

1. Undissolved Phase is Distributed Throughout A Vehicle and Intended for Oral Administration.

2. In This Preparation This phase Is Called ‘Dispersed phase’ and the Vehicle Is called ‘Dispersed Medium’.

3. It’s also called Internal Phase or External Phase respectively. The Need for Biphasic Liquid Dosage Forms arises When the Medicaments are Poorly Soluble in the Solvent medium.

4. Medicaments From The Dispersed Phase Of The System Which Might Be Either Solid Or Liquid.

5. When Solid Medicament is Distributed in the Dispersion Medium, the System Formed Is Called SUSPENSION.

6. When Liquid Medicament is Distributed in the Dispersion Medium, The System Formed is Called EMULSION.
These Two Highly unstable Systems are made Stable By Employing various Pharmaceutical aids Like; SUSPENDING AGENT , EMULSIFYING AGENT.

7. They are Categorised as Coarse Particles , Usually 1 To 100 Microns in Size.

8. Dispersion Containing particles of smaller Size are called Fine Dispersion and If the Particles are In the Colloidal Range ( less than1 Micron ), They are termed MAGMAS.

Types Of Biphasic Liquid
There Are Two Types Of Biphasic Liquid:-
1. SUSPENSION
2. EMULSION
1. SUSPENSIONS are categorised into Enemas, Lotion, Inhalation, Aerosols, Eye Drop.
2. EMULSIONS Are Categorised into Liniment, Lotion, Enemas.

SUSPENSION: It is a heterogeneous biphasic dosage form, solid is dispersed in a liquid medium.

EMULSION: An emulsion is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is immiscible.

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