New Study: 29% Improvement In Alzheimer’s Disease?!

A new human study has shown a 29% improvement in the cognitive abilities of Alzheimers Disease Patients when they were given a combination of supplements.

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Here are the links to the research papers referenced in the video:

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#Alzheimers #Longevity

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[DrBradStanfield]

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[Vgallo]

This is now my new fav health channel, rigorous research and intellectually honest, that last one immediately puts you on top as it’s such a rare trait for humans in General.

[oibal]

Those of us who have watched a parent, or both, pass through the various stages of 'forgetfulness' right through to full on dementia, then death by starvation... thank you for this.

[stephaniehenderson]

This is great news, thank you for taking a close look and sharing your opinion 😀😀. I am currently caring for my 87 year old mother with mixed dementia and any ray of hope is comforting to me. I am taking most of your stack already and doing what I can with the lifestyle issues.

[kdub]

As a fellow physician, I appreciate and encourage the focus on the statistical analysis of the studies discussed. TU

[rudylampas]

Thanks Doc. For giving us hope, May God bless you and your family 🙏

[Alexyourm]

Nootropic Depot NAC I’ve been taking since beginning of Covid and will continue rest of my life. Not just brain, but does so much for the body

[robertcunningham]

So nice to have evidence base / non-dogma reviews of supplements and other homeopathic remedies that we can all learn from. Keep up the good work!

[LTPottenger]

Very interesting! Low carb and fasting are also shown to have a good effect. Some of the many benefits of doing occasional extended fasting: Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. Blood pressure is quickly and dramatically lowered. Fribrosis/scarring is reversed over time and telomeres are lengthened, which also helps with lung fibrosis. Reflexes and short term memory are increased.

Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system.

After 72 hours or more fasted, your body recycles large numbers of immune bodies and creates new ones, rejuvenating your entire immune system.

Vitamin D plasma levels are increased, and vitamin D in turn increases autophagy!
Fasts from 36-96 h actually INCREASE metabolic rate due to norepinephrine release!

Weight loss from fasting only loses10% lean tissue and 90% fat compared to the typical 25% lean tissue and 75% fat lost when calorically restricting for long periods. The hunger hormone ghrelin lowers with extended fasting and rises from dieting.

Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.

When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.

What breaks a fast? Anything with protein or carbohydrates in it will break a fast, though if the amount is tiny you will go back into ketosis very quickly. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many medications are dangerous to take while fasting so you may have to talk to your dr. about discontinuing them during a fast.

Fasts of several days will not affect short term female fertility and may increase long term fertility, especially in women with PCOS.

Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone and helps build muscle by increasing insulin sensitivity!

The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!

Does the body preferentially prefer glucose as a fuel? No, your body always runs mainly on fat except for brief periods of very intense exercise. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose.

Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells. AMPK does many helpful things in the body including activating the body's antioxidant defenses.

Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which also help your immune system and anti-oxidative system, especially in the brain. Ketones also provide an additional energy source during infection, which is critical when trying to fight off a bug. In fact you can have as much as three times the total energy available in your blood when you are in deep ketosis, or even more.

It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!

When you fast, this stimulates apoptosis in senescent or genetically damaged cells. This kills these cells off completely. Senescent cells are responsible for the effects of aging and are the root cause of the development of cancer. If it were possible to destroy them all it would completely stop aging and cancer. That is not possible but fasting can help limit these effects by killing off many of the affected cells and limiting the future effects of aging.

Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth, helping a great deal with diseases like MS, peripheral neuropathy and Alzheimers.

In fact, the biochemical regulator of BDNF production is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting.

Fasting also increases telomere length, negating some of the effects of aging at a cellular level.

A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and under 18 g of carb.

Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.

Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.

Resources:










This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!

My channel which will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics.

[evelynross]

Thanks Dr. Brad.
You are doing an incredibly important service here. By doing what you do at the level you’re doing it.
Simply Brilliant. Good Job!

[rafaelortega]

The amyloid theory is seriously questioned after the scandal that was unfolded last year

[fatihzent]

I'm not sure If there is a data of Alzheimer patients based on Demografics but as a Turkish, it is a very common disease. Almost in every family either Grandma or grandpa has a neurological disease. makes me so happy to see that this study is conducted in Turkey.

[sojournerhouse]

Your videos and information are the best of the best! I listen to a lot of videos and read books about nutrition. I am so happy I found your channel. FYI: collagen link is broken.

[JonathanOvnat]

Would love to see a video by you about contaminations in supplements (heavy metals etc.) and what levels are really safe. Would also like a video about molecular hydrogen supplements.

[ranganathA]

Hi Brad,
Thank you for trying to come up with a formulation for this dreadful disease. Your video is about a year old, but I do not see any comment that your formula has helped someone. Are you sure your formula really helps? What is the missing link? Please make a comment about why no one has had a positive outcome thus far.

[michaelcapaldi-grwn]

Brad:


Great stuff. So many of us appreciate your careful, balanced approach to supplementation.


In two of your videos over the last few months, you have said studies suggest that, in order support mitochondrial function and insulin resistance, keeping NAC and Glycine in balance may be desirable. I believe you have said that, after age 45, you would consider 1.5 grams of each of Glycine and NAC, twice daily.

On the other hand, you have also discussed taking one gram of Trimethylglycine (TMG), to reduce high homocysteine levels that may contribute to dementia.


Question: If one desires to keep NAC and Glycine in balance, taking, let's say, 3 grams of each in the course of a day, would one compromise that balance by also taking 1 gram of TMG?


Or may TMG and Glycine be taken in those amounts (with the above volume of NAC) without compromising that balance?


We'd be interested in your thoughts.

[darthvader]

0:29 to 0:48 to 1:21
0:29
Alzheimer's disease is closely
0:31
associated with metabolic abnormalities
0:33
and oxidative stress linked to critical
0:35
elements of neurodegeneration such as
0:38
mitochondrial dysfunction and
0:39
bioenergetic impairment so it's hoped
0:42
that by supporting the brain's
0:43
metabolism and reducing the oxidative
0:45
stress we can improve the brain's
0:46
function and therefore cognitive
0:48
abilities this is a really interesting
0:50
approach because although Alzheimer's
0:52
disease is defined by an accumulation of
0:54
abnormal amyloid proteins sulfur amyloid
0:57
lowering approaches have failed to
0:59
provide any cognitive benefits in human
1:01
clinical trials essentially we can see
1:03
from scans that there is this buildup of
1:05
amyloid proteins but the existing
1:07
therapies that have been trialled to
1:08
lower amyloid buildup they've failed so
1:11
it's time for a new approach where a
1:12
growing body of evidence suggests that
1:14
impaired brain energy metabolism and
1:16
mitochondrial dysfunction in Alzheimer's
1:19
disease May contribute to the cognitive
1:21
decline therefore by combining multiple
1:23
compounds to reduce this oxidative
1:24
injury we may be able to Target multiple
1:27
Pathways at the same time so let's go
1:29
through each of the four ingredients to
1:31
make sure that we understand the
1:32
underlying Theory as to how these
1:34
combined metabolic activators will
1:36
improve brain performance Alzheimer's
1:38
disease brains appear to have lower
1:39
glutathione levels so glutathione is a
1:42
powerful antioxidant and by taking the
1:44
building blocks of glutathione we can
1:46
help rebuild our glutathione levels so

[baileystruss]

Very interesting. On a side note, recent research suggests a strong correlation of alzheimers with lifetime viruses exposure or illness

[TinaWinterbourne]

Love all your content. My mother is showing signs of dementia, repeating things a number of times in the same conversation and focusing on very trivial things. Her conversation has become very child like. Hoping to speak with her doctor to check on these supplements for her. I have heard methylene blue and red light are also very helpful, as well as lions mane. Would love to hear from you on these substances. Thanks for all your hard work.

[davidsoares]

Serine plays an important role in fat metabolism. The high dose of Serine may have just as much to do with fat metabolism as it has to do with glutathione production. To combination of Serine and Carnitine may create a synergistic fat burning effect that is greater than either of the two on their own.