What is a tauopathy?

Boyd Ghosh, MBBS, PhD, University Hospital Southampton, Southampton, UK, gives an introduction to tauopathies and their various clinical presentations. The term tauopathy is used to describe neurodegenerative disorders characterized by tau deposits in the brain. More than 20 tauopathies have been identified that present with a range of phenotypes. Heterogeneous symptom presentation and overlapping pathology can complicate diagnosis and treatment. In primary tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), tau is the prominent component of the pathology, whereas in secondary tauopathies, including Alzheimer’s disease, tau accumulation is thought to be a response to other pathology. While tau protein abnormalities are central to the pathophysiology, the underlying mechanisms involved in these diseases are complex and much remains unknown. This interview took place at The BNA 2023 International Festival of Neuroscience in Brighton, UK.

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