Metabolizing Alzheimer’s: A New Key to Stopping Brain Damage

Alzheimer's disease is a metabolic disease where brain cells, including neurons and their support cells called astrocytes, struggle to produce and process energy. This energetic failure contributes to dementia. New research published in Science has identified a key protein in brain metabolism, IDO1, that contributes to energy crisis in Alzheimer’s disease.

In this video, I’ll break down the latest findings and explain how this pathway can be targeted to slow or prevent Alzheimer's progression. Stay until the end for my high-level recommendations to protect yourself from dementia today.

#alzheimersdisease #brainhealth #metabolichealth

Chapters
0:00 – New paper: Alzheimer’s is a metabolic disease
0:52 – Brain metabolism background: Astrocytes and Lactate
1:32 – IDO1 enzyme is a Key Player in Alzheimer’s disease
3:09 – How to Rescue Brain Metabolism with Cancer Drug
4:33 – 4 Practices to Protect Against Dementia

[bradp]

Nick, this is my new favorite channel. Love your content. Clear and concise presentation on topics that are quite relevant to the life of me and my family.

[billtrudell]

One thing that I used that got rid of brain fog as it's called is Acetyl-L-carnitine. I'm a software engineer and I'm 66. I seriously thought I would need to retire due to basically not being able to think well enough to perform my job. I started taking it along with a keto diet I had been on for a couple of years without any improvement but after adding Acetyl-L-carnitine that all changed. My brain seriously needed energy and was failing but now it's working better than I ever remember. I struggle through most of my life but it got so bad I was ready to give up. Now in the daily scrum my manager did something I never heard him say that my updates were among the best he's heard. Clear consise. It doesn't sound like much but for a guy who spent most of my life trying not to talk because I couldn't depend on the words coming out it is amazing to me.

[DCGreenZone]

Hal Cranmer in his 3 retirement homes in Mesa Arizona, had dementia residents, he made a deal with the children of these residents, he made them swear off bringing in donuts, candy, chips etc. He put them on meat, period. Many regained their cognizance, some went home to live a normal life. The video title is This is scary. Shawn Baker is the man who interviewed him.

[heftyjo]

I've been taking care of my Mom for the past 3 years and she is in the moderate stages of Alzheimer's. When I first moved in to help take care of my aging parents I noticed my Mom was eating a bunch of junk food. The fridge was full of 12 packs of Cokes and the pantry had 4 or 5 bags of potato chips. My parents were also eating tons of take out and fast food. So, they were eating tons of processed food full of seed oils, lots of sugars, and deep fried foods. And they also loved to slather margarine on their food. She has difficulty talking and quite often has bouts of paranoia and hallucinations. Also needs help with self care going to the bathroom and getting dressed. Also she has badly swollen legs that required XXL socks just to fit over the ankles. So, yea she is having all kinds of metabolic issues.

I've taken control of her diet and cut way back on the sugar intake and when I do give her a little coke as a treat I give her a Mexican Coke with the real cane sugar instead of fructose corn syrup stuff. I stopped the potato chips entirely as I learned that those cause uric acid inflammation. And I've cut the seed oils back quite a bit and thrown out all the margarine. I try to make a majority of her dinners from scratch and only use Olive oil and real butter when preparing foods. Last visit to the neurologist and they noted that her verbal skills seemed to be improving. And I can certainly see she is doing better with self care and getting dressed on her own. And she hasn't told me she sees people walking around in the house for a while now. Also the swelling in her legs has reduced quite a bit and we can actually wear normal sized socks again. I really do believe that a large percentage of chronic diseases are pathologically linked to poor diets. And my parents were certainly a victim of the disastrous low fat, high carb food pyramid scam that was foisted on the public.

[ngana]

To reduce your risk of dementia:
1. Exercise: 4:48 min
2. Adequate sleep: 5:05 min
3. Long-chain omega 3 fatty acids (EPA and DHA) in your diet,
4. Lower carb and higher fat diet for those with a genetic risk factor for Alzheimer's (APOE4 allele).5:48 min
5. Enjoy life 6:04 min

[raviboppudi]

Nick, Love your short and sweet videos. Thanks for the education.
My mom was vegetarian(due to religious reasons) and was diagnosed with Parkinson's around 2.5 years ago. Her protein intake was minimal.
Last November I spent time with her and changed her diet and increased Paneer and Whey protein. Almost Keto.
No more Parkinson's symptoms. Her shuffling of feet(while getting up from a chair) and shaking of hands stopped completely.
I managed to convince her to eat 2 eggs per day and she is much stronger and active right now.
I thank all the Drs like you, Dr BAker, Dr Berry, Dr Bikman, Dr Bredesen who post educational videos on SM.

[tristanhnl]

GREAT advice towards the end of the video. My dad currently has advanced alzheimer's, and does not even know how to hold a spoon to feed himself. He's essentially a big infant, needs someone to feed, bathe, and change his diaper everyday. The time when his dementia started accelerating....was when he retired and literally stayed home every single day, and hardly EVER ventured outside the house. He rarely had guests/friends over. That's why the advice at the end of this video resonates with me so far. Go outside, get exercise, enjoy life, enjoy friends, companionship and fellowships, get lots of

[benwallman]

Nick, you forgot to mention that omega 3 supplementation has no benefit when homocysteine is high (b12 status low) and supplementing b12 without omega 3 has no benefit. Supplementing methyl b12 AND omega 3 shows HUGE benefit for dementia. This is clearly shown in the literature and a shame you missed it, worth reposting with the edit!

[RizwanMuzzammil]

I would add one more thing: Get adequate sunlight. Not just for the UV which helps with Vitamin D production, but also IR, which helps clear oxidative stress. Also, switch off any night lights while sleeping.

[ndp]

Hal is far more informative than the Alzheimer’s Society and others! Keep up the good messaging Hal!

[elloohno]

The pictures help so much with understanding what you are saying. This is very interesting!
Thank you

[karenbuchert]

Hello Nick! That was an amazing video!!! Cascades of thanks to you for your videos you create for us. Your showmanship and design were awesome for the public to enjoy, follow, and understand, and you gave us a wrap up homework assignment in eating smash fish! Your enunciation and rate were fabulous. The visual aids were just right also. They really kept the viewer tied into your message. Thank you, Nick!! ❤❤

[drsvs]

This is one of your best, Nick. Please know your efforts are greatly appreciated.

[scaler]

Love the presentation style, showing the simplified breakdown of the metabolic processes involved. Great video!👍

[joannamazur]

I love your channel....I thoroughly enjoy your videos and the subject matter that you cover...without dumbing it down..❤

[aprilek]

Bravo Nick, This may be one of your best overall videos yet. I love the science review and then the helpful suggestions to keep your brain healthy. It will be interesting to see if this drug will be repurposed and offered to patients. I recently read Dr. Paul Marik's book, Cancer Care The Role of Repurposed Drugs and Metabolic Interventions in Treating Cancer. You are making a difference Nick keep it up

[twiggyfitness]

Another great video... and perfect timing, I shared it with a friend who needs to hear this information .

[cynthiafasulo]

Watched this again. You give so many hope in so many ways. Thank you, Nick.

[kennethyuman]

SMASH: salmon, mackerel, anchovy, sardine and herring. I failed to capture the snapshot as they swam away quickly

[zacharylark]

Nick, great video. You explain the topic and the subject in a fantastic way. It was information dense and well ordered. Definitely going to rewatch it and share it with a few folks.