Methylene Blue: Biohacker's Delight, or Playing With Fire

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Get whole genome sequenced so you know why you would even need to consider MB:

00:00:00 The Origin of Methylene Blue

00:08:54 The Entry of Methylene Blue Into Medicine

00:13:59 From Malaria to Many Uses in Medicine

00:26:20 How Methylene Blue Works

A Redox-Reactive Dye

The Blue Bottle Experiment

Methylene Blue Radicals, Photoexcited States, and Demethylated Metabolites

Methylene Blue Can Oxidize and Reduce Many Targets

Methylene Blue Can Rewire the Mitochondrial Respiratory Chain

Rewiring the Respiratory Chain Does Not Make It Better

Methylene Blue Increases Hydrogen Peroxide

Hydrogen Peroxide Kills Microbes, Has Hormetic Benefits, But Is Still Ultimately Toxic

Methylene Blue Causes Redox Cycling of Hemoglobin

Methylene Blue Is a Strong Monoamine Oxidase A Inhibitor

Methylene Blue Inhibits Nitric Oxide Synthase

Mechanistic Conclusions

02:09:14 Is Methylene Blue Fundamentally Hormetic?

02:15:06 Methylene Blue Fails in Alzheimer’s, and Causes a Worrisome Side Effect

02:23:57 Whether Methylene Blue Helps Or Hurts Depends on Whether You Need It

02:30:16 Natural Alternatives for Hormesis and Rewiring the Respiratory Chain

02:33:27 Who Should Use Methylene Blue?

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[richardmalone]

I have been taking MB 40mg per day for 4 months after listening to Dr.Francisco Gonzalez-Lima. Gradual improvements over that time have been, improved sleep quality and much improved cognitive function in the area of maintaining my attention on a task. I am 69 and work full time and my occupation requires my full and complete attention for extended periods. Prior to using MB, I was considering retirement but now I am back to working well with full attention.

[benniejohnson]

Thank you for this great resource and also the helpful comments.
I began experimenting with MB probably 6 months ago. For many weeks I took only 4-5 drops every day (64 yrs old/175lbs). That is a very low dose but it was enough to help me to begin to move forward from the grief of losing my lovely wife to cancer after 42 years of marriage and children. It seemed to help with my mental and emotional energy when engaging in conversation during social interactions.
I also drive a lot in my work, and sometimes all day. I would take 4 drops just before a long drive and noticed that it helped me to remain more alert without the need for stimulants.
For now, I don’t take it every day. But I’ve taken it twice during the past week just before some all day drives and still impressed with it. So glad to have found it. Hope this helps someone.

[XviRV]

Thank you. Excellent deep dive into the mechanisms of action. Those of you that complain about the length of the video, and quality of the sound, should be grateful that someone takes the time to share their knowledge to such a degree for your education. Keep up the great work.

[AdrianK-dv]

Bravo! I am a physician who recently became interested in the potential benefits and risks of MB. You saved me hours of research, including an in-depth refresher in biochem. Extremely helpful. Thank you. Liked and subscribed.

[johnmurdock]

Thanks so much for this comprehensive presentation. You've saved all of us a great deal of time compiling this academic research. You must have spent hundreds of hours digging through countless journals and books to produce this video. Excellent work!

[edwardbryan]

An amazing marathon effort. Thanks, too, to the author for making this available as a PDF. Very grateful for the resource.

[AZMYTHKAMINSKI]

The main reason there’s a contraindication with MB and SSRIs is because of a theoretical rat study of upwards of 8 mg per kilogram of body weight and higher which interacted with SSRIs and increased serotonin capable toxicity levels.

MB is at low dosage a very safe alternative to the massively negative side effects causing pharmaceutical SSRIs of today.

Great information overall dock. Well done being more comprehensive than anybody’s video I’ve seen on methylene blue!
👏👏👏

[heartsource]

20 mg methylene blue makes me calm and motivated. I use it occasionally, as a substitute for psychiatric medicine like bensodiazepine.

[stefcat]

Using low dose oral MB has had unexpected benefits for me. It has eliminated a fungal condition that I could not take medication for, unexpectedly, as I was using MB for help with something else. Thanks for the detailed info.

[rnkim]

at about 139:00 he explains that at properly functioning kreb cycle with healthy mitochondria and no defects- that the hIghest amount of ATP (ENERGY UNITS) are created already. MB goes around this normal functioning system which can save you during a defectively functioning kreb cycle, but its at a loss of ATP and at the risk of metabolites you must process... in vitro vs in vivo are discussed earlier and a good foundation of chemistry and physiology are really helpful to understand this most excellent presentation and synthesis of information on this video. youre welcome to all of you complaining its too long and hard to understand. he does an EXCELLENT job of explaining the history and studies and his conclusions for those of you who dont get it. this is the most complete and interesting delve into pretty much any subject matter ive seen here on youtube... im so impressed at the knowledge and organization it took to make this presenatation❤

[locosmiley]

People complain about a guy who spent 3 hrs of his time making a video for free. Shameless

[freethoth]

You definitely made me feel I should proceed with caution. I had observed elevated blood pressure from it even before seeing your presentation. Others made it sound like a total godsend. Thank you.

[crfogal]

I appreciate the great detail of the subject. I note the Orthodox icon. This reassures me you have attention for historical details and truth. Thank you for your good efforts. 🙏🕯☦️❤️

[GoldenBlaisdale]

I started looking into methylene blue sometime ago.

I was nervous to take it, and I ended up contacting Dr Gonzalez, who was very helpful.

I have been taking it daily for months and months and see no particular downsides.

It’s certainly has increased energy. And it seems to have helped a healing tooth abscess which was rather nastily infected.

My mother suffers with cognitive impairment, and I’ve been microdosing her and it seems to be having quite a remarkable effect.

Of course, these are just personal anecdotes. In my mother’s case, she doesn’t even know what I’m giving her so it can’t be Placebo.

[TheSpecialJ]

I take 1mg, not per kilogram, total, and am experiencing noticeable benefits. I almost certainly have mitochondrial damage that I need to work to heal, maybe from mold, maybe from SARS-CoV-2, maybe from both. I'm working on healing, but in the meantime, Methylene Blue has been a game changer for me.

[rs]

I would like to present my own version about MB. 1. Low dose is beneficial, high dose can be toxic. Start with 2 drops gradually increase to 10 -20 drops according to how your body reacts and your body weight. 2. Check long list of drugs that can cause side effects with MB before taking MB. 3. Consider enhancing energy production with MB plus near infrared light therapy. 4. Drop MB in some juice, chasing down with water to avoid blue stain and bad taste. 5. This is not a natural nutrient. Use it as needed. Take breaks from MB from time to time.

[FrancesHart]

I have been taking MB 30 mg per day for over 6 months and am very senior in age. I experience increased energy, work capacity, and cognitive function. I work full time and study. I have just started C60 in extra virgin olive oil daily, and am getting out my near infra red light Wellbeam device again. I also take fisetin. I hope to have time to get back to the gym in the coming months.

[rixgaming]

Microdosing this right now (one drop of 1%solution a day) and it helps a lot with the autism.

[brakeme]

That's exactly what happened to me. I used it till I got better. I knew I was better because it flat out didn't feel good anymore.

[maschoff]

I am fighting candida and it is helping a lot.

The sharing of electrons of the double bonds causes the conformational change which makes the molecule reflect all light. It reflects blue light otherwise.