CRISPR is genome vandalism | Manolis Kellis and Lex Fridman

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[tanxyrogue]

Most clear explanation of CRISPR I've ever heard

[ticket]

This guy is a real professional. Would be great to have more of this on youtube.

[BradHolkesvig]

If you think of everything as information, then it's easier to understand. Information is used to change other information. You can also think of a pond of water that is completely still. Then by throwing a stone in that water, it changes the appearance of the water in that pond. This is information changing information.

[questionable-ethics]

Can anyone recommended some resources to learn more about cripsr and its methods of use

[eugkra]

this yogurt industry is going to be a trillion dollar industry one day when it starts to cure aging.

[filipg]

The one question regarding gene editing I always had is how does the DNA modification propagate through your entire body? Where do you need to make this gene change doesn’t every cell in your body contain your genome? Do you need to make the edit in every cell at once?

[tomlloyd]

Beam doesn’t cut the genome, it chemically changes one side and nicks the other side to change each letter. No more cutting needed

[MM-qweo]

The whole 2hrs or so was pretty cool too

[ericbriggs]

Manolis is so damn good at explaining complex shit like this.

[kipling]

It's refreshing to see my field be a revelation to Lex, e.g., CRISPR-CAS9 technology, instead of always me trying to keep up the computer/AI stuff.

[rifz]

I wish the link to full episode was time stamped to the end of this, so I can carry on with this part..
great show! thanks!

[YusufOthmanSheriff]

Thanks so much,
I never had any idea of CRISPR is about

[theflyingcrud]

This is fantastic! Such a clear and concise explanation, I'm blown away. Thank you for this!

[nancyling]

I finally understand how CRISPR works.

[AtlasReburdened]

Ahh, so the beauty of CRISPR is that it's infinitely more accessible as a method of bio-terrorism. Here's a simple question I'm sure no bio-terrorist would eeeever ask. What happens if you modify a retrovirus to integrate a CRISPR 'kit' that seeks out the sequences responsible for building the molecular machines that do the repairing?...

[mitcr]

He means non homologous end joining when DNA repairs itself naturally. However, homology directed repair is considered a DNA repair mechanism when you introduce a repair vector - an insertion of a piece of DNA you choose

[patrickschissler]

If CRISPR isn't a technological development you find to be existentially terrifying (or at the least morally abhorrent), then you are not thinking on a deep enough level to be charged with the responsibility to develop, refine, and determine the moral validity of developing such technologies.

[son_go_ma]

I just used a variant of this to cut the links in my brain that knew 'stuff' about CRISP-R and "fixed it" using the explanation that was given to Lex. Much better, awesome explanation.
Thanks for the assist, cousin! :D

[LM]

CRISPR is referenced in a kids movie called Spies in Disguise

[noclue]

This all sounds fascinating, but not knowing much about it.
Sounds like one more thing that could eventually end humanity.