Cholinergic and Anticholinergic Toxicity (Toxidrome)

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[armandohasudungan]

📌 MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓

[mumbos]

The funny thing is, its thought that anticholinergic substances were actually thought to be involved in the writing of Alice in wonderland. A mushroom known as aminita muscaria with gabaurgic and anticholinergic effects was likely consumed by the author of the book, being a big source of inspiration in its writing

[gabogalaiz]

This is why i follow you, you're the maaan

[IxDarkxNinjaxI]

Nice video. I survived anticholinergic toxicity, neuroleptic malignant syndrome and severe antipsychotic withdrawal symptons all at the same time.

[Saffron-sugar]

Anticholinergic used to be the “horror movie“ toxidrome: red as blood, mad as a hatter, dry as a bone, blind as a bat (dilated pupils), hot as hell . Anticholinergic toxidrome has certainly changed since I was in medical school. They used to say “hot as hell“ but that seems to have been changed to “hot as a hare”. But why is a hare hot? The full urinary retention is new to me. But great to mention! Especially in comparison to Cholinergic poisoning.

[dilashmathapa]

These mnemonics are very helpful, thanks.

[HamCubes]

I wanna be the very best,
Like no one ever was!

[tlee]

What is the difference between muscarinic cholinergic vs. nicotinic cholinergic toxidromes?

[StevePhillips]

Brilliant ways to remember thank you man!!!

[cascarney]

I love you videos, this one is great as always!
But shouldn't it be "salivation" instead of "salvation" in SLUDGE?

[guibyalknosee]

Is a chronical cholinergic crisis a possible thing? I'm asking because after just three doses of choline alfoscerate at 400 mg, I developed a bunch of torturous symptoms. For more than six weeks I have been constantly in a depressed, anxious, desperate mood. I have no appetite at all (I hardly can eat), I have ringing in the ears, bradycardia, thready pulse, impaired circulation, increased intestinal peristalsis, fatigue, chills, sweating, slight fever, weakness and other crazy parasympathetic effects. Is it theoretically possible that, for some unknown reason, my acetylcholine level does not decrease and even gradually accumulates, which leads to such symptoms?

This hypothesis came to my mind for the following reasons:
1) The antidepressants prescribed to me only affect my mood but have no effect on the "muscarinic" symptoms, like bradycardia. It looks like a mood disorder is one of the manifestations of the disease, and not the disease itself.
2) Atropine temporarily relieves my condition
3) A dose not exceeding 1 mg of atropine does not even raise my pulse
4) Over time, the effectiveness of atropine decreases. Since I use it only in extreme cases, my body's adaptation to it is doubtful.
5) If acetylcholine does not accumulate in my body, then the disease would go away by itself, since cholinesterase would quickly remove excess acetylcholine

So how to reduce the level of acetylcholine in my body or, if this is not possible, how to block excess acetylcholine? What medications are best for this?

[sc]

I have been trying to understand better why I had mental health crisises immediately after herbicide exposure.
It seems like I was a mix of the sludge monster and alice...

Can you explain why it might have been that I went to both extremes?

( I am a long time nicotine user which I think might play a role. Also curious if some ancestries have more muscarinic receptors than others?)

[Romeo]

Sir plz make a video with adrenergic and cholinergic pharmacology....

[BBCeiz]

Mr Armando can you give to them lectures about arrhythmia there is a difficulty in understanding this object

[rishikwatt]

Pokémon? What is that? I mean, come on.

[MrEthanhines]

How can something that activates the Parasympathtic Nervous System (the one used for relaxing) cause death as in Sarin....?!