4. Enzymes & Metabolism

MIT 7.016 Introductory Biology, Fall 2018
Instructor: Barbara Imperiali

After a brief re-cap of the last lecture, Professor Imperiali continues with amino acids, peptides, and proteins, with a focus on a protein variant that is the cause of sickle cell anaemia. She then introduces enzymes for the remainder of class.

License: Creative Commons BY-NC-SA

[melusimgwenya]

this series has reminded me how interesting biology is

[CharteriousLiberax]

The polymer protein stand carrying the Peptide carboxylic ameno chain, carrying primary genetic sequence for autonomous Operation production is missing from your Chromosome stick recount uptake.
Your body collects polymer protein stand's from each autonomous system for G_nome Dna replication.
Is that correct?
Is the sickling caused by Iron Oxide as a Hexide Polygon bonded molecules that are imobile for renal expulsion?

[송예은-hb]

Thank you MIT for this course! So helpful in my studies:)

[GadgetMuhsin]

Great lecture, but what she said about the choice of Enthalpy vs Entropy argument IS INCORRECT. It is a bit long to explain clearly, so I am not doing that, but please do look it up.

[rakhiar]

21:47 should be corrected to glutamic acid not carboxylic right?
18:03 I am sure functional properties of the RBCs are hugely impacted by this base pair change as well as protein interactions. Sickle cell anemia adopts a rough pushed structure compared to its normal biconcave disc structure that largely influences a spacious surface area required for oxygen binding and transportation. Wouldnt this be hindered when RBCs beta globin is mutated forming a sickle shape and adopting a structure with a much more smaller surface area. On top of that limiting oxygen binding and transportation across the body.

[sderese]

Cat(cut)abolic @39, that is how I remeber 🙏 for a great lecture

[woloabel]

(On Sunday of January 29, 23023). Introductory to Biology: 1) Enzyme (Reactive Protein) and Metabolism (The Collective Processes both Catabolic and Anabolic In A Homeostasis Context); The Ideal of Substrate to Product Always Involves a Chemical Reaction (Catalytically Driven by a Protein) usually by a DNA Molecule-Encoded Protein (Rather than a Denatured, Spontaneous or Pathological Protein [Prion]); Pharmacology has the best of time with the Identification of the Protein and Processes of a Disease (Receptor-Ligand Identification) and the best of the profits in the Pharmacologic Inhibition (Although Agonism is Another Therapeutic Venue); The best of therapeutic However employ DNA-Encoded Proteins (ie Immunoglobulins [Antibodies and Recombinant Human Antibodies) and Links these with the Actual Pharmacologic Entity (The Best of Chemotherapeutics because of High Specificity and Metabolism Thereafter Yields Less Non-Targeted Toxicity). Here too the Bonding (Non-covalent for the Links) and the 150 kDa Monoclonal Antibody (Which is the Epitome of Sensitivity and Specificity in Any Case); Enzymes and the Proteomics therein are not the same as it was 10 Years let alone 50 Years Ago; Anyway, the best to those who deserve the Optimum (Optima est Mea Imperatrix) PhD Barbara Imperiali. Heil!

[MasonRVs]

I was under the impression that Tyrosine was Polar Uncharged? Is this a point of contention amongst biologists or was I misinformed?

[farahali]

ليس مجالي علمي فانا ادبي ولكن احب اتعلم

[مريم-فقث]

Is hemoglobin heterotetrameric or homotetrameric as the prof mentioned?

[mohammedbleiblo]

what confused me is, Haemoglobin, isn't a quaternary structure protein?

[helios]

does someone have the slides (PPT)? please