Resisting An Increased Epigenetic Speed Of Aging (14-Test Results)

Discount Links:
Use Code: CONQUERAGING

Use Code: ConquerAging At Checkout

Enter Code: ConquerAging

Use Code: CONQUERAGING At Checkout

------------------------------------------------------------------------------------------------------------------------------------------------
Papers referenced in the video:
Underlying features of epigenetic aging clocks in vivo and in vitro

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

[jamesgilmore]

Bryan Johnson revealed that they think it was either a peptide or the follistatin gene therapy that dropped his DunedinPACE. In my opinion the follistatin gene therapy seemed more likely. Previously to this he said many of the longevity interventions they were trying were increasing his DunedinPACE.

[barrie]

fascinating stuff with professional presentation, glad i stumbled on your channel Sir

[jamesgilmore]

Mike -- tough situation. Some suggestions: 1) The omega 3 correlation is worth assessing with fish oil and/or flaxseed oil, very little downside it seems. 2) I would redo the analysis excluding the high-dose nicotinic acid point at 0.98. There is also the point at 0.89, but I don't know what was happening there (NMN?), but I'd try that as well to generate more ideas. 3) Treat the high-dose nicotinic acid point as a case study (and the 0.89?) and see what else changed from baseline both before and after in all your data. That should generate some hypothesis about what changes this for the negative and you can then work forwards. Perhaps make a video about it. 4) Would it be possible to label each point with the experiments you were conducting during each time frame? Maybe some patterns will show up. 5) Since these tests are reliant on blood spots it would be good to label any anomalies in RBC's and WC's, as some of the earlier clocks aren't robust against those changes.

[djblame]

Awesome video!

In addition to brocolli sprouts what sprouts do you recommend for anti aging?

[chris-lkml]

Maybe you'll find some correlations with sports and your favorite type of relaxarion methods

[NofLongevityQuest]

I'm still struggling to understand Caloric Restriction. Let's say I am a 56yo female weighing 109 lbs with a BMR of 1300 calories per day and another 500 calories burned during running and daily movement. So theoretically, if I ate 1800 calories each day, I would stay at exactly the same weight and that would qualify as zero caloric restriction. It seems that if I ate 12% less than this, my weight would continually decrease in very slight increments. If 109 is already my goal, how is caloric restriction good for me? Maybe I just still don't understand the concept.

[adamd]

Thanks for an informative video as usual. It's surprising that there isn't anything specifically in your diet that correlated to the Dunedin pace of aging. Although it appears that the # of calories does.

[YuraL]

There are 2 obvious outliers at 3:07, one of them is even close to 1. Do you have any idea/hypothesis what might have caused them?

[dirkheyer]

Vitamin D, Magnesia, Carotinoids, Lifestyle and Sports should be also important for methylation.
I know there is a study about Vitamin D and methylation, maybe done in 2022.🤔 ...and for Vitamin D is Magnesia/K2 an important faktor, maybe also Gut Bacteria, with some you get older and they can be a pre faktor for DNA methylation.

[justsaying]

What happened to your hypothesis that LDL is negatively correlated with DunedinPace? (I’m doubtful about this hypothesis.) I believe you increased saturated fat and cholesterol intake to raise LDL to test the hypothesis.

[ChessMasterNate]

Have you considered combining all the different kinds of epigenetic tests together that you do, looking for correlations with foods? Quick and dirty would just be averaging all the correlations for each food, but now with a larger number of tests, significance may be achieved.

[darrenparis]

The DunedinPACE does not correlate with your diet components - OK

What about other factors? Did you find any?

[monnoo]

was't grimage showing the best association with ACM?
In my opinion, hose age clocks need to be related to a wide vector of physiological markers, and to health events like cancer, or CVD, in a cohort that has not chronic disease and a healthy body composition. Using ACM is already integrating the treatment aspect and should not be used as endpoint.
Those aging clocs are all based on a weak theory, IMO, which s why they use chronological age on both side of the equation....
I think the proper approach would be to have as much classical markes as possible arranged in a vector / profile, and then determining the (non-euclidean) distance of your data to a youthful condition. That distance you could track over time. it would make much more sense than those fancy marketing tools.

[newdata]

can double check w total calories/protean vs the test result

[MikeG-jsjt]

its $500 how the hell are you spending this much money on all this testing, I understand some of us have more than others, but sheesh! to spend it on this so often seems a little ridiculous.