What is the Cori Cycle? | Gluconeogenesis Explained Simply

The Cori Cycle is one way that the body can metabolize lactate into glucose.

This is one metabolic pathway of gluconeogenesis (Creating New Glucose) that is done in the liver.

*The muscles can also do gluconeogenesis directly in the muscle cell (Especially type 1 fibers)

In the cori cycle, lactate is transported through the bloodstream, into the liver and converted to pyruvate then glucose.

Additional Questions:

1: How quickly is lactate cleared?

Lactate is typically back to a resting concentration within 1 hour post exercise. This time is faster when an active cool down is utilized.

2: What goes through gluconeogenesis?

In addition to lactate, glycerol (after lipolysis), and amino acids can go through gluconeogenesis to be used for energy.

3: What hormones are involved in gluconeogenesis?

Glucagon, Cortisol, Catecholamines (Epinephrine/ Norepinephrine), Thyroid Hormone, and Growth Hormone.

4: What does the liver do?

In addition to the cori cycle, the liver breaks down glycogen polymers into glucose as well as plays a role in metabolism and storage of many nutrients. It also plays an important role in excretion of cholesterol, hormones, and drugs.

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00:20 Path of Blood Glucose
01:40 Path of Pyruvate
02:00 Cori cycle
02:30 What is Gluconeogenesis?
03:05 Is this the only way to clear lactate?
03:25 How long does it take to clear lactate?
03:45 What else goes through gluconeogenesis?
04:00 How does this interact with the endocrine system?
04:37 Why is the liver important?

Make sure you check out some of the other CSCS Prep Videos I have done:

Comment below if you have any questions!

Disclaimer: This video does not have any affiliation with, or any recognition, sponsorship, or endorsement by, the NSCA. CSCS® and Certified Strength and Conditioning Specialist® are registered trademarks of the National Strength and Conditioning Association.

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[MzAlexZ]

Bro not even my lecturers at med school explain it as clear as you do. Thank you!!

[ambermillerstrengthco]

I have a masters degree in ex physiology and have never had a professor explain this as clearly as you 🙌🏻💪🏻👍🏻

[MsGigiiiiiGoNZalEZ]

I really appreciate how you think of including questions we might have and how certain concepts can be applied to clients. This all really helps with the overall picture.

[hanumavattem]

Helped me understand the concept easily and clearly, thanks man

[Basedstruggler]

Youtubers always explain things so clearly and quickly haha, one of the best ways to study. Thank you.

[raininglavender]

such a great yet simple explanation, thank you for this!

[birdscrytoo]

Loved the diagram!! Made it so much simpler

[manshikk]

Bc..itni si chiz ko samjhne k liye me meri nind kharab kar rahi thi .. bro ne 4 minutes me samjha Diya 😭😭😭 thanks 🥺🥰

[faythegmiller]

thank you, I was watching another video and got so confused. This video helped to straighten my thinking a bit

[lizasem]

appreciate the nice drawings. Helps me visualise better! keep the content coming Matt!

[rdance]

I've been a gym rat since I was 10 years old, 1975. I retired at age 53 due to extreme metabolic fatigue but learned to hack several of my genetic SNPs. I was so successful that I dropped below 10% bodyfat and gained more muscle. I was on the way to physique competitions when things started going South. One of the things that happened was that I would get extreme muscle soreness from workouts that wouldn't normally cause me to get sore. I also became more and more fatigued. I believe now, that I have it figured out. I believe that I have a Thiamine deficiency. I think this is causing two things. Since Alpha Ketoglutarate Dehydrogenase (Thiamine Dependant) is the rate limiting enzyme to the TCA cycle, my Oxidative Phosphorilation is being inhibited. Also, Pyruvate Dehydrogenase (Thiamine Dependant) is causing Pyruvate to build up, leading to increased Lactic Acid Fermentation. Do you agree with this possibility? I have many more symptoms that aligin with Thiamine Deficiency. I just want to know if my reasoning makes sense.

[tranedTurtle]

Keep up the great content man so much valuable info in such a short video🙏

[vairaggya]

Nice explanation sending love from India ❤

[smileunice]

This is SIMPLE and STRAIGHTFORWARD. THANK YOU!

[yomnaosama]

This helped ALOT ! simple yet effective explanation, thanks . Happily subscribed.

[oliviaamoako]

You're the best!!! Thank you for simplifying this withing 5 minutes 😀

[clockedinathletics]

after 10 years of trying to learn this. I finally get it.

[radhaparashar]

Thanks, that diagram was so good, I will definitely add it in my notes, Love from India✨♥️

[chasole]

Great explanation of the Cori Cycle. I am a 60-year old pre-diabetic (no medications) and wear a continuous glucose monitor to track my glucose. When I start doing a vigorous activity like tennis singles, my glucose will spike from 100 to over 200 after 30 minutes of playing. Within 20 minutes of stopping play, the blood glucose returns to around 100. Is the Cori Cycle involved in this?

[spectroxis]

second he said glut 4 I was like ok this guy really knows his shit.